The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants
Few studies have described the dynamics of haemoglobin production in African populations with a high prevalence of haemoglobinopathies. We have used the BioRad Variant ClassicTM HPLC method to document the production patterns of the common haemoglobin variants HbA, HbA2, HbF and HbS, stratified by a...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2018
|
| _version_ | 1826263460245143552 |
|---|---|
| author | Macharia, A Uyoga, S Ndila, C Nyutu, G Makale, J Tendwa, M Nyatichi, E Ojal, J Atkinson, S Williams, T |
| author_facet | Macharia, A Uyoga, S Ndila, C Nyutu, G Makale, J Tendwa, M Nyatichi, E Ojal, J Atkinson, S Williams, T |
| author_sort | Macharia, A |
| collection | OXFORD |
| description | Few studies have described the dynamics of haemoglobin production in African populations with a high prevalence of haemoglobinopathies. We have used the BioRad Variant ClassicTM HPLC method to document the production patterns of the common haemoglobin variants HbA, HbA2, HbF and HbS, stratified by a+thalassaemia genotype, among 15,301 infants recruited to a study on the Coast of Kenya. Notably, we confirm that HbA2 measurements determined using this instrument are unreliable in HbAS and HbSS subjects. Further, we showed that HbA2 exceeded 4.0%, a level consistent with the presence of a-thalassaemia, in 0.8% of infants of HbAA phenotype who participated in our study. a-thalassaemia, has not been widely reported in the East Africa region and, as such, this finding merits further study. |
| first_indexed | 2024-03-06T19:52:07Z |
| format | Journal article |
| id | oxford-uuid:244f456d-6658-4d4d-b833-0accabf66da5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:52:07Z |
| publishDate | 2018 |
| publisher | Ferrata Storti Foundation |
| record_format | dspace |
| spelling | oxford-uuid:244f456d-6658-4d4d-b833-0accabf66da52022-03-26T11:49:21ZThe population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infantsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:244f456d-6658-4d4d-b833-0accabf66da5EnglishSymplectic Elements at OxfordFerrata Storti Foundation2018Macharia, AUyoga, SNdila, CNyutu, GMakale, JTendwa, MNyatichi, EOjal, JAtkinson, SWilliams, TFew studies have described the dynamics of haemoglobin production in African populations with a high prevalence of haemoglobinopathies. We have used the BioRad Variant ClassicTM HPLC method to document the production patterns of the common haemoglobin variants HbA, HbA2, HbF and HbS, stratified by a+thalassaemia genotype, among 15,301 infants recruited to a study on the Coast of Kenya. Notably, we confirm that HbA2 measurements determined using this instrument are unreliable in HbAS and HbSS subjects. Further, we showed that HbA2 exceeded 4.0%, a level consistent with the presence of a-thalassaemia, in 0.8% of infants of HbAA phenotype who participated in our study. a-thalassaemia, has not been widely reported in the East Africa region and, as such, this finding merits further study. |
| spellingShingle | Macharia, A Uyoga, S Ndila, C Nyutu, G Makale, J Tendwa, M Nyatichi, E Ojal, J Atkinson, S Williams, T The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title | The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title_full | The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title_fullStr | The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title_full_unstemmed | The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title_short | The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants |
| title_sort | population dynamics of haemoglobins a a2 f and s in the context of the haemoglobinopathies hbs and α thalassaemia in kenyan infants |
| work_keys_str_mv | AT machariaa thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT uyogas thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT ndilac thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT nyutug thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT makalej thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT tendwam thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT nyatichie thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT ojalj thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT atkinsons thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT williamst thepopulationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT machariaa populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT uyogas populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT ndilac populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT nyutug populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT makalej populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT tendwam populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT nyatichie populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT ojalj populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT atkinsons populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants AT williamst populationdynamicsofhaemoglobinsaa2fandsinthecontextofthehaemoglobinopathieshbsandathalassaemiainkenyaninfants |