A novel domain suggests a ciliary function for ASPM, a brain size determining gene.

A novel domain suggests a ciliary function for ASPM, a brain size determining gene.

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The N-terminal domain of abnormal spindle-like microcephaly-associated protein (ASPM) is identified as a member of a novel family of ASH (ASPM, SPD-2, Hydin) domains. These domains are present in proteins associated with cilia, flagella, the centrosome and the Golgi complex, and in Hydin and OCRL wh...

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Xehetasun bibliografikoak
Egile nagusia:	Ponting, C
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2006

Antzeko izenburuak

A novel domain suggests a ciliary function for ASPM, a brain size determining gene
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A novel splice-site mutation in the ASPM gene underlies autosomal recessive primary microcephaly
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Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis
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Expression of ASPM in Lung Adenocarcinoma and Its Relationship with Development and Prognosis
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ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules
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Correction: Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis
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Implementation Framework for Robust Detection, Synchronization, and Decoding of M-ASPM Communications
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Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression.
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RETRACTED: ASPM predicts poor prognosis and regulates cell proliferation in bladder cancer
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Identification of a wide spectrum of ciliary gene mutations in nonsyndromic biliary atresia patients implicates ciliary dysfunction as a novel disease mechanism
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Screening ANLN and ASPM as bladder urothelial carcinoma-related biomarkers based on weighted gene co-expression network analysis
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The microtubule-associated protein ASPM regulates spindle assembly and meiotic progression in mouse oocytes.
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ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
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ASPM May be Related to the Malignant Progression of Hepatitis B and is Associated With a Poor Prognosis of Hepatocellular Carcinoma
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Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia
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Novel domains and orthologues of eukaryotic transcription elongation factors.
nork: Ponting, C
Argitaratua: (2002)

Ciliary genes are down-regulated in bronchial tissue of primary ciliary dyskinesia patients.
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Argitaratua: (2014-01-01)

Gene expression and functional annotation of the human ciliary body epithelia.
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Novel function of a primary ciliary dyskinesia-associated protein in myeloid cells
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Tone and genes: New cross-linguistic data and methods support the weak negative effect of the "derived" allele of ASPM on tone, but not of Microcephalin.
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Ciliary body size in chronic angle-closure glaucoma
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Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
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Argitaratua: (2010-11-01)

ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway
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Argitaratua: (2022-01-01)

Loss of Aspm causes increased apoptosis of developing neural cells during mouse cerebral corticogenesis
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Evidence for impaired olfactory function and structural brain integrity in a disorder of ciliary function, Usher syndrome
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Whole exome sequencing identifies a novel homozygous frameshift mutation in the ASPM gene, which causes microcephaly 5, primary, autosomal recessive [version 1; referees: 2 approved]
nork: Desaraju Suresh Bhargav, et al.
Argitaratua: (2017-12-01)