High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.

High level transcription of the complement regulatory protein CD59 requires an enhancer located in intron 1.

CD59 is a complement regulatory protein and may also act as a signal-transducing molecule. CD59 transgenic mice have been generated using a CD59 minigene (CD59 minigene-1). Although this minigene contained a 4.6-kilobase pair 5'-flanking region from the human CD59 gene as a promoter, the expres...

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Bibliografiska uppgifter
Huvudupphovsmän:	Tone, M, Diamond, L, Walsh, L, Tone, Y, Thompson, SA, Shanahan, E, Logan, J, Waldmann, H
Materialtyp:	Journal article
Språk:	English
Publicerad:	1999

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av: Rudd, P, et al.
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av: Bodian, D, et al.
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