Effects of point mutations in pVHL on the binding of HIF-1α.

The von Hippel-Lindau tumor suppressor protein (pVHL) has an essential role in the regulation of the hypoxia response pathway in animal cells. Under normoxic conditions, the hypoxia-inducible factor (HIF) undergoes trans-4-prolyl hydroxylation and is subsequently recognised by the β-domain of pVHL,...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Domene, C, Illingworth, C
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2012