Effects of point mutations in pVHL on the binding of HIF-1α.
The von Hippel-Lindau tumor suppressor protein (pVHL) has an essential role in the regulation of the hypoxia response pathway in animal cells. Under normoxic conditions, the hypoxia-inducible factor (HIF) undergoes trans-4-prolyl hydroxylation and is subsequently recognised by the β-domain of pVHL,...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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