Effects of point mutations in pVHL on the binding of HIF-1α.

The von Hippel-Lindau tumor suppressor protein (pVHL) has an essential role in the regulation of the hypoxia response pathway in animal cells. Under normoxic conditions, the hypoxia-inducible factor (HIF) undergoes trans-4-prolyl hydroxylation and is subsequently recognised by the β-domain of pVHL,...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Domene, C, Illingworth, C
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2012