Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.
The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 A resolution and refined to an R-factor of 0.219 (for all data) with good stereochemistry. The unliganded structure was produced by soaking out a weak binding non-nucleoside inhibitor, HEPT, from pregrown crystals. C...
主要な著者: | , , , , , |
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フォーマット: | Journal article |
言語: | English |
出版事項: |
1995
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