Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.

The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 A resolution and refined to an R-factor of 0.219 (for all data) with good stereochemistry. The unliganded structure was produced by soaking out a weak binding non-nucleoside inhibitor, HEPT, from pregrown crystals. C...

詳細記述

書誌詳細
主要な著者: Esnouf, R, Ren, J, Ross, C, Jones, E, Stammers, D, Stuart, D
フォーマット: Journal article
言語:English
出版事項: 1995