Synthetic tools for studying the chemical biology of InsP8

Synthetic tools for studying the chemical biology of InsP8

Čájet eará veršuvnnaid (1)

To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural an...

Bibliográfalaš dieđut
Váldodahkkit:	Riley, A, Wang, H, Shears, S, Potter, BVL
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	Royal Society of Chemistry 2015

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Synthetic tools for studying the chemical biology of InsP8
Dahkki: Riley, A, et al.
Almmustuhtton: (2015)

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase
Dahkki: Riley, A, et al.
Almmustuhtton: (2012)

Synthesis of an α-phosphono-α,α-difluoroacetamide analogue of the diphosphoinositol pentakisphosphate 5-InsP7
Dahkki: Riley, A, et al.
Almmustuhtton: (2019)

Effect of Phytate (InsP6) and Other Inositol-Phosphates (InsP5, InsP4, InsP3, InsP2) on Crystallization of Calcium Oxalate, Brushite, and Hydroxyapatite
Dahkki: Paula Calvó, et al.
Almmustuhtton: (2023-06-01)

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP5
Dahkki: Shipton, ML, et al.
Almmustuhtton: (2023)

Cellular internalisation of an inositol phosphate visualised by using fluorescent InsP5
Dahkki: Riley, A, et al.
Almmustuhtton: (2013)

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia–reperfusion injury by elevating plasma adiponectin
Dahkki: Fu, L, et al.
Almmustuhtton: (2024)

Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.
Dahkki: Chunfang Gu, et al.
Almmustuhtton: (2016-01-01)

Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism.
Dahkki: Satish Kumar, et al.
Almmustuhtton: (2011-01-01)

Cytosolic [Ca2+] regulation of InsP3-evoked puffs.
Dahkki: Yamasaki-Mann, M, et al.
Almmustuhtton: (2013)

Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP<sub>7</sub>
Dahkki: Soumyadip Sahu, et al.
Almmustuhtton: (2023-01-01)

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.
Dahkki: Kasri, N, et al.
Almmustuhtton: (2004)

The role of Ca2+ signalling and InsP3R in the pathogenesis of intrahepatic cholestasis of pregnancy
Dahkki: Dan Pan, et al.
Almmustuhtton: (2024-12-01)

One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP<sub>8</sub> Occurs under Cytosolic Conditions
Dahkki: Leonie Kurz, et al.
Almmustuhtton: (2023-04-01)

The Binding Mechanism Between Inositol Phosphate (InsP) and the Jasmonate Receptor Complex: A Computational Study
Dahkki: Mengqi Cui, et al.
Almmustuhtton: (2018-07-01)

Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes.
Dahkki: Nidhi Kapoor, et al.
Almmustuhtton: (2014-01-01)

Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia
Dahkki: Manivannan Subramanian, et al.
Almmustuhtton: (2013-05-01)

ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein
Dahkki: Horia Vais, et al.
Almmustuhtton: (2020-05-01)

Complexes of myo-inositol-hexakisphosphate (InsP6) with zinc or lanthanum to enhance excretion of radioactive strontium from the body.
Dahkki: Kazuma Ogawa, et al.
Almmustuhtton: (2018-01-01)

Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.
Dahkki: Harzheim, D, et al.
Almmustuhtton: (2009)

MICU2 Restricts Spatial Crosstalk between InsP3R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU
Dahkki: Riley Payne, et al.
Almmustuhtton: (2017-12-01)

Three-Dimensional Model of Sub-Plasmalemmal Ca2+ Microdomains Evoked by the Interplay Between ORAI1 and InsP3 Receptors
Dahkki: Diana Gil, et al.
Almmustuhtton: (2021-04-01)

Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells.
Dahkki: Mohammad Alimohammadi, et al.
Almmustuhtton: (2017-01-01)

Synthesis of D-myo-inositol 1,4,5-trisphosphate (InsP3) derivatives via a novel Ferrier rearrangement
Dahkki: Keddie, N, et al.
Almmustuhtton: (2008)

Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves
Dahkki: Simon Restrepo, et al.
Almmustuhtton: (2016-08-01)

Sperm-Induced Ca<sup>2+</sup> Release in Mammalian Eggs: The Roles of PLCζ, InsP<sub>3</sub>, and ATP
Dahkki: Karl Swann
Almmustuhtton: (2023-12-01)

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.
Almmustuhtton: (2005-12-01)

Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulum
Dahkki: J. Kevin Foskett, et al.
Almmustuhtton: (2004-01-01)

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.
Dahkki: Peter J Mohler, et al.
Almmustuhtton: (2005-12-01)

Alzheimer’s Disease-associated peptide Aβ42 mobilises ER Ca2+ via InsP3R-dependent and -independent mechanisms
Dahkki: Laura E Allan, et al.
Almmustuhtton: (2013-11-01)

Both D- and L-glucose polyphosphates mimic D-myo-inositol 1,4,5-trisphosphate: new synthetic agonists and partial agonists at the Ins(1,4,5)P3 receptor
Dahkki: Brearley, CA, et al.
Almmustuhtton: (2020)

UUM launches fund for late Insp Zulkifli's family
Dahkki: New Sabah Times English, (KK)
Almmustuhtton: (2013)

The location of InsP3 receptors in Purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between ER and mitochondria
Dahkki: Ramesh Iyer, et al.
Almmustuhtton: (2021-08-01)

Mammalian sperm contain a Ca(2+)-sensitive phospholipase C activity that can generate InsP(3) from PIP(2) associated with intracellular organelles.
Dahkki: Rice, A, et al.
Almmustuhtton: (2000)

OSCILLATIONS AND WAVES IN A MODEL OF INSP3-CONTROLLED CALCIUM DYNAMICS
Dahkki: Othmer, H, et al.
Almmustuhtton: (1993)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
Dahkki: Watt, J, et al.
Almmustuhtton: (2018)

Ca2+ store dynamics determines the pattern of activation of the store-operated Ca2+ current I(CRAC) in response to InsP3 in rat basophilic leukaemia cells.
Dahkki: Glitsch, M, et al.
Almmustuhtton: (2000)

Correction to: InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by promoting cytosolic Ca 2+ elevation and TBK1 activity
Dahkki: Long Yang, et al.
Almmustuhtton: (2020-11-01)

PLCζ Induced Ca2+ Oscillations in Mouse Eggs Involve a Positive Feedback Cycle of Ca2+ Induced InsP3 Formation From Cytoplasmic PIP2
Dahkki: Jessica R. Sanders, et al.
Almmustuhtton: (2018-04-01)

The excitation cascade of <it>Limulus </it>ventral photoreceptors: guanylate cyclase as the link between InsP<sub>3</sub>-mediated Ca<sup>2+ </sup>release and the opening of cGMP-gated channels
Dahkki: Lisman John E, et al.
Almmustuhtton: (2004-02-01)