Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment

<strong>Objective:</strong> Most healthcare interventions provide modest benefits, but occasionally trials report very large improvements over existing treatments or inactive controls. This often leads to speculation that further trials may be unnecessary. We examined whether a very larg...

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Detalhes bibliográficos
Main Authors: Nagendran, M, Pereira, T, Kiew, G, Altman, D, Maruthappu, M, Ioannidis, J, McCulloch, P
Formato: Journal article
Idioma:English
Publicado em: BMJ Publishing Group 2016