The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.

The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.

The aim of this study was to determine whether antimalarial agents inhibit ATP-sensitive potassium (K(ATP)) channels and thereby contribute to the observed side-effects of these drugs. Mefloquine (10 - 100 microM), but not artenusate (100 microM), stimulated insulin release from pancreatic islets in...

書誌詳細
主要な著者:	Gribble, F, Davis, T, Higham, C, Clark, A, Ashcroft, F
フォーマット:	Journal article
言語:	English
出版事項:	2000

類似資料

The antimalarial drugs mefloquine and halofantrine inhibit ATP-sensitive potassium channels
著者:: Gribble, F, 等
出版事項: (1997)

Correlating structure and function in ATP-sensitive K+ channels.
著者:: Ashcroft, F, 等
出版事項: (1998)

Mechanism of K-ATP channel inhibition by ATP
著者:: Ashcroft, F, 等
出版事項: (1998)

Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
著者:: Gribble, F, 等
出版事項: (1998)

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.
著者:: Ashcroft, F, 等
出版事項: (1999)

Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
著者:: Gribble, F, 等
出版事項: (1999)

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
著者:: Trapp, S, 等
出版事項: (1998)

A model for regulation of the beta-cell ATP-sensitive K+-channel by nucleotides and diazoxide.
著者:: Tucker, S, 等
出版事項: (1997)

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
著者:: Trapp, S, 等
出版事項: (1998)

Dynamic sensitivity of K-ATP channels to ATP
著者:: Loussouarn, G, 等
出版事項: (2001)

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.
著者:: Loussouarn, G, 等
出版事項: (2001)

New windows on the mechanism of action of K(ATP) channel openers.
著者:: Ashcroft, F, 等
出版事項: (2000)

Properties and functions of ATP-sensitive K-channels.
著者:: Ashcroft, S, 等
出版事項: (1990)

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
著者:: Reimann, F, 等
出版事項: (2003)

Differential activation of cloned K-ATP channels by nicorandil
著者:: Reimann, F, 等
出版事項: (2001)

Regulation of K-ATP channels by nucleotides and drugs
著者:: Gribble, F, 等
出版事項: (2000)

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
著者:: Tucker, S, 等
出版事項: (1997)

Interactions between tolbutamide and nucleotides on cloned K-ATP channels.
著者:: Gribble, F, 等
出版事項: (1997)

How ATP inhibits the open K(ATP) channel.
著者:: Craig, T, 等
出版事項: (2008)

The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.
著者:: Gribble, F, 等
出版事項: (1997)

ATP sensitivity of the ATP-sensitive K+ channel in intact and permeabilized pancreatic beta-cells.
著者:: Tarasov, A, 等
出版事項: (2006)

Tissue-specific effects of sulfonylureas: lessons from studies of cloned K(ATP) channels.
著者:: Ashcroft, F, 等
出版事項: (2000)

Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.
著者:: Ashfield, R, 等
出版事項: (1999)

Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel
著者:: Trapp, S, 等
出版事項: (1998)

A touching case of channel regulation: the ATP-sensitive K+ channel.
著者:: Tucker, S, 等
出版事項: (1998)

Expression of the cloned beta-cell ATP-sensitive potassium channel in Xenopus oocytes
著者:: Gribble, F, 等
出版事項: (1996)

Molecular determinants of KATP channel inhibition by ATP.
著者:: Tucker, S, 等
出版事項: (1998)

Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.
著者:: Gribble, F, 等
出版事項: (1997)

Inhibition of ATP-sensitive potassium channels by haloperidol.
著者:: Yang, S, 等
出版事項: (2004)

Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.
著者:: Gribble, F, 等
出版事項: (1998)

Identification of the high affinity tolbutamide site on the SUR1 subunit of the K-ATP channel
著者:: Gribble, F, 等
出版事項: (1999)

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
著者:: Reimann, F, 等
出版事項: (1999)

The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells.
著者:: Niki, I, 等
出版事項: (1989)

Inhibition of cloned K-ATP channels by stilbene disulphonates
著者:: Proks, P, 等
出版事項: (2000)

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.
著者:: Gribble, F, 等
出版事項: (1998)

Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
著者:: Teerachat Saeheng, 等
出版事項: (2023-01-01)

Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria.
著者:: Teerachat Saeheng, 等
出版事項: (2023-01-01)

Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.
著者:: Clark, R, 等
出版事項: (2012)

Mice expressing a human K ATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities
著者:: Clark, R, 等
出版事項: (2012)

The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.
著者:: Gribble, F, 等
出版事項: (1997)