Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...

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Príomhchruthaitheoirí:	Luchetti, G, Sircar, R, Kong, J, Nachtergaele, S, Sagner, A, Byrne, E, Covey, D, Siebold, C, Rohatgi, R
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	eLife Sciences Publications 2016

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