The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes.

Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove introns that are present in most protein-coding transcripts. The recent discovery of a variety of somatic spliceosomal mutations in the myelodysplastic syndromes (MDS), a heterogeneous group of myelo...

詳細記述

書誌詳細
主要な著者: Boultwood, J, Dolatshad, H, Varanasi, S, Yip, B, Pellagatti, A
フォーマット: Journal article
言語:English
出版事項: 2014