Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme

<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...

وصف كامل

التفاصيل البيبلوغرافية
المؤلف الرئيسي: Holt-Martyn, J
مؤلفون آخرون: Schofield, C
التنسيق: أطروحة
منشور في: 2018