GTPCH I overexpression decreases atherosclerotic lesion formation in apolipoprotein E-deficient/eNOS transgenic mice

Antzeko izenburuak

• Increased GTP-cyclohydrolase I expression but not vitamin C treatment restored accelerated atherosclerotic lesion formation in apolipoprotein E-deficient mice overexpressing endothelial nitric oxide synthase
  nork: Takaya, T, et al.
  Argitaratua: (2004)
• Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
  nork: Alp, N, et al.
  Argitaratua: (2002)
• Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
  nork: Bendall, J, et al.
  Argitaratua: (2005)
• Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
  nork: Bendall, J, et al.
  Argitaratua: (2004)
• A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression.
  nork: Takaya, T, et al.
  Argitaratua: (2007)