Interpretation of somatic POLE mutations in endometrial carcinoma

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours (‘POLE‐ultramutated’) within the novel molecular classification of endometrial carcinoma (EC). However, clinical implementation of this classifier re...

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Detalles Bibliográficos
Main Authors: León-Castillo, A, Britton, H, McConechy, MK, McAlpine, JN, Nout, R, Kommoss, S, Brucker, SY, Carlson, JW, Epstein, E, Rau, TT, Bosse, T, Church, DN, Gilks, CB
Formato: Journal article
Idioma:English
Publicado: Wiley 2020