Interpretation of somatic POLE mutations in endometrial carcinoma

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours (‘POLE‐ultramutated’) within the novel molecular classification of endometrial carcinoma (EC). However, clinical implementation of this classifier re...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: León-Castillo, A, Britton, H, McConechy, MK, McAlpine, JN, Nout, R, Kommoss, S, Brucker, SY, Carlson, JW, Epstein, E, Rau, TT, Bosse, T, Church, DN, Gilks, CB
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Wiley 2020