Targeting DNA repair nucleases in cancer

Targeting DNA repair nucleases in cancer

<p>The human enzyme Apollo/SNM1B is a 5′-3′ exonuclease implicated in two aspects of genome integrity, both the response to DNA damage, where it is proposed to play a role in double-strand break (DSB) and interstrand crosslink (ICL) repair and telomere maintenance, where it resects leading str...

Mô tả đầy đủ

Chi tiết về thư mục
Tác giả chính:	Henderson, LR
Tác giả khác:	McHugh, P
Định dạng:	Luận văn
Ngôn ngữ:	English
Được phát hành:	2023
Những chủ đề:	DNA damage Telomere biology

Những quyển sách tương tự

Telomere-related DNA damage response pathways in cancer therapy: prospective targets
Bằng: Liting Gu, et al.
Được phát hành: (2024-06-01)

Systematic Analysis of the DNA Damage Response Network in Telomere Defective Budding Yeast
Bằng: Eva-Maria Holstein, et al.
Được phát hành: (2017-07-01)

Editorial: Nuclear Genome Stability: DNA Replication, Telomere Maintenance, and DNA Repair
Bằng: Marcelo S. da Silva, et al.
Được phát hành: (2022-03-01)

Dyskerin Mutations Present in Dyskeratosis Congenita Patients Increase Oxidative Stress and DNA Damage Signalling in <i>Dictyostelium Discoideum</i>
Bằng: Javier Rodriguez-Centeno, et al.
Được phát hành: (2019-11-01)

Cellular DNA effects of radiation and cancer risk assessment in cells with mitochondrial defects
Bằng: J. Chen, et al.
Được phát hành: (2022-03-01)

Elucidating the factors required for activation of the alternative lengthening of telomeres pathway
Bằng: Goncalves, T
Được phát hành: (2023)

DNA damage checkpoint adaptation genes are required for division of cells harbouring eroded telomeres
Bằng: Sofiane Y. Mersaoui, et al.
Được phát hành: (2015-09-01)

Rif1: a conserved regulator of DNA replication and repair hijacked by telomeres in yeasts
Bằng: Stefano eMattarocci, et al.
Được phát hành: (2016-03-01)

PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage
Bằng: Wareed Ahmed, et al.
Được phát hành: (2020-11-01)

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions
Bằng: Dechao Cao, et al.
Được phát hành: (2019-05-01)

Telomere maintenance and the DNA damage response: a paradoxical alliance
Bằng: Ashley Harman, et al.
Được phát hành: (2024-10-01)

Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction
Bằng: Zeliha Yalçin, et al.
Được phát hành: (2017-05-01)

Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Bằng: Yuanlong Ge, et al.
Được phát hành: (2019-05-01)

A qPCR-based assay to quantify oxidized guanine and other FPG-sensitive base lesions within telomeric DNA
Bằng: Nathan O'Callaghan, et al.
Được phát hành: (2011-12-01)

Characterization of the EBV-Induced Persistent DNA Damage Response
Bằng: Amy Y. Hafez, et al.
Được phát hành: (2017-12-01)

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer
Bằng: Vikas Kumar Bhari, et al.
Được phát hành: (2021-07-01)

Editorial: Proceedings From ACCM19: Cell Cycle, DNA Damage Response and Telomeres
Bằng: Andrew Burgess, et al.
Được phát hành: (2020-09-01)

Acacetin and Chrysin, Two Polyphenolic Compounds, Alleviate Telomeric Position Effect in Human Cells
Bằng: Amina Boussouar, et al.
Được phát hành: (2013-01-01)

DNA repair and cancer : from bench to clinic /
Bằng: Wilson, David M., 1967- 545425, et al.
Được phát hành: (2013)

Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance
Bằng: Huilin Zhou, et al.
Được phát hành: (2012-10-01)

Telomeres and Cell Senescence - Size Matters Not
Bằng: Stella Victorelli, et al.
Được phát hành: (2017-07-01)

Small molecules, inhibitors of DNA-PK, targeting DNA repair and beyond
Bằng: David eDavidson, et al.
Được phát hành: (2013-01-01)

A cell‐based model system links chromothripsis with hyperploidy
Bằng: Balca R Mardin, et al.
Được phát hành: (2015-09-01)

Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition
Bằng: Claire Ghilain, et al.
Được phát hành: (2021-07-01)

Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes
Bằng: Gabriel Lidzbarsky, et al.
Được phát hành: (2018-04-01)

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
Bằng: Yingjie Ji, et al.
Được phát hành: (2019-06-01)

The role of TIRR in DNA damage and repair
Bằng: Ketley, R
Được phát hành: (2022)

DNA damage (8-OHdG) and telomere length in captive Psittacidae birds with different longevity
Bằng: Angélica Domínguez-de-Barros, et al.
Được phát hành: (2024-08-01)

TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres
Bằng: Rosa Maria Porreca, et al.
Được phát hành: (2020-01-01)

Emerging roles of interferon-stimulated gene-15 in age-related telomere attrition, the DNA damage response, and cardiovascular disease
Bằng: María González-Amor, et al.
Được phát hành: (2023-03-01)

Interactions between the DNA Damage Response and the Telomere Complex in Carcinogenesis: A Hypothesis
Bằng: Antonio Torres-Montaner
Được phát hành: (2023-09-01)

Natural Compounds That Target DNA Repair Pathways and Their Therapeutic Potential to Counteract Cancer Cells
Bằng: Francisco Alejandro Lagunas-Rangel, et al.
Được phát hành: (2020-11-01)

α-Terpineol Induces Shelterin Components TRF1 and TRF2 to Mitigate Senescence and Telomere Integrity Loss via A Telomerase-Independent Pathway
Bằng: Marianna Kapetanou, et al.
Được phát hành: (2024-10-01)

Telomere attrition and inflammation: the chicken and the egg story
Bằng: J. P. Shirley Niveta, et al.
Được phát hành: (2022-08-01)

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis
Bằng: Krishna P. Maremanda, et al.
Được phát hành: (2020-09-01)

Loss of telomere protection: consequences and opportunities.
Bằng: Jacqueline Johanna Leonarda Jacobs
Được phát hành: (2013-04-01)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
Bằng: Hiroshi Ebata, et al.
Được phát hành: (2022-06-01)

Novel insights into the genetic and epigenetic paternal contribution to the human embryo
Bằng: Manoj Kumar, et al.
Được phát hành: (2013-01-01)

ShaPINg cell fate upon DNA damage:role of Pin1 isomerase in DNA damage-induced cell death and repair
Bằng: Thomas G Hofmann, et al.
Được phát hành: (2014-06-01)

Core-Extended Naphthalene Diimide Dyads as Light-Up Probes with Targeted Cytotoxicity Toward Tumor Cells
Bằng: Valentina Pirota, et al.
Được phát hành: (2025-02-01)