Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions.
The cytoskeletal protein talin binds to a short C-terminal sequence in phosphatidylinositol phosphate kinase type Igamma (PIPKIgamma), activating the enzyme and promoting the local production of phosphatidylinositol 4,5 bisphosphate, which regulates focal adhesion dynamics as well as clathrin-mediat...
Hoofdauteurs: | de Pereda, J, Wegener, K, Santelli, E, Bate, N, Ginsberg, M, Critchley, DR, Campbell, I, Liddington, R |
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Formaat: | Journal article |
Taal: | English |
Gepubliceerd in: |
2005
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