Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse

Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels of which predict poor outcomes in human cardiovas...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Lygate, CA, Lake, HA, McAndrew, DJ, Neubauer, S, Zervou, S
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Frontiers Media 2022

Antzeko izenburuak

Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
nork: Craig A. Lygate, et al.
Argitaratua: (2022-08-01)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
nork: McAndrew, DJ, et al.
Argitaratua: (2022)

Homoarginine and creatine deficiency do not exacerbate murine ischaemic heart failure
nork: Debra J. McAndrew, et al.
Argitaratua: (2023-02-01)

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine
nork: Faller, K, et al.
Argitaratua: (2017)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
nork: Maguire, ML, et al.
Argitaratua: (2023)

Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure
nork: Atzler, D, et al.
Argitaratua: (2017)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart
nork: Aksentijević, D, et al.
Argitaratua: (2014)

Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure
nork: Cao, F, et al.
Argitaratua: (2020)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro
nork: Zervou, S, et al.
Argitaratua: (2017)

Synergistic effect on cardiac energetics by targeting the creatine kinase system: in vivo application of high-resolution 31P-CMRS in the mouse
nork: Mahon L. Maguire, et al.
Argitaratua: (2023-02-01)

Screening for small molecule regulators of the creatine transporter (SLC6A8)
nork: Zervou, S, et al.
Argitaratua: (2020)

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.
nork: Dunja Aksentijević, et al.
Argitaratua: (2014-01-01)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
nork: Zervou, S, et al.
Argitaratua: (2010)

Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion
nork: Whittington, H, et al.
Argitaratua: (2018)

Augmentation of creatine kinase in vitro protects against simulated ischaemia reperfusion injury
nork: Zervou, S, et al.
Argitaratua: (2017)

Protective effect of creatine elevation against ischaemia reperfusion injury is retained in the presence of co-morbidities and during cardioplegia.
nork: Whittington, H, et al.
Argitaratua: (2016)

Creatine uptake in mouse hearts with genetically altered creatine levels.
nork: ten Hove, M, et al.
Argitaratua: (2008)

Chronic Creatine-deficiency is not the Underlying Cause of Cardiac Dysfunction in Mice Lacking the Creatine Biosynthetic Enzyme Arginine: glycine Amidinotransferase
nork: Lygate, C, et al.
Argitaratua: (2013)

New insights into the creatine kinase-phosphocreatine energy buffer and transport system using mouse models of altered creatine content
nork: Lygate, C, et al.
Argitaratua: (2006)

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.
nork: Zervou, S, et al.
Argitaratua: (2016)

Subtle role for adenylate kinase 1 in maintaining normal basal contractile function and metabolism in the murine heart
nork: Zervou, S, et al.
Argitaratua: (2021)

The creatine kinase system as a therapeutic target for myocardial ischaemia-reperfusion injury
nork: Cao, F, et al.
Argitaratua: (2018)

Age-dependent decline in cardiac function in guanidinoacetate-N-methyltransferase knockout mice
nork: Aksentijević, D, et al.
Argitaratua: (2019)

The creatine kinase energy transport system in the failing mouse heart
nork: Lygate, C, et al.
Argitaratua: (2006)

The creatine kinase energy transport system in the failing mouse heart.
nork: Lygate, C, et al.
Argitaratua: (2007)

The amino acid homoarginine inhibits atherogenesis by modulating T-cell function
nork: Nitz, K, et al.
Argitaratua: (2022)

Protective Effect of Creatine Elevation against Ischaemia Reperfusion Injury Is Retained in the Presence of Co-Morbidities and during Cardioplegia.
nork: Hannah J Whittington, et al.
Argitaratua: (2016-01-01)

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
nork: Sevasti Zervou, et al.
Argitaratua: (2017-01-01)

A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis.
nork: Zervou, S, et al.
Argitaratua: (2013)

REGULATION OF CELLULAR CREATINE HOMEOSTASIS: A ROLE FOR THIOREDOXIN INTERACTING PROTEIN (TXNIP)
nork: Zervou, S, et al.
Argitaratua: (2013)

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
nork: Lygate, C, et al.
Argitaratua: (2012)

Regulation of Myocardial Creatine Uptake by Intra- and Extracellular Creatine Levels
nork: Makinen, K, et al.
Argitaratua: (2008)

Unchanged Mitochondrial Organization and Compartmentation in Creatine Deficient GAMT-/- Mouse Heart
nork: Branovets, J, et al.
Argitaratua: (2013)

Maintaining energy provision in the heart: the creatine kinase system in ischaemia-reperfusion injury and chronic heart failure
nork: Lygate, CA
Argitaratua: (2024)

Living without creatine: Unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice
nork: Lygate, C, et al.
Argitaratua: (2013)

Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
nork: Lygate, C, et al.
Argitaratua: (2013)

The pitfalls of in vivo cardiac physiology in genetically modified mice -- lessons learnt the hard way in the creatine kinase system
nork: Lygate, CA
Argitaratua: (2021)

Guanidine production by plant homoarginine-6-hydroxylases
nork: Dietmar Funck, et al.
Argitaratua: (2024-04-01)

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism
nork: Malte Stockebrand, et al.
Argitaratua: (2018-06-01)

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age
nork: Lygate, C, et al.
Argitaratua: (2012)