Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

<p>This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The fir...

Fuld beskrivelse

Bibliografiske detaljer
Hovedforfatter:	Wijeyekoon, JB
Andre forfattere:	Pugh, C
Format:	Thesis
Sprog:	English
Udgivet:	2013
Fag:	Medical Sciences Clinical laboratory sciences

Lignende værker

Regulation of HIF: prolyl hydroxylases.
af: Stolze, I, et al.
Udgivet: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
af: Chowdhury, R, et al.
Udgivet: (2016)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
af: Rasheduzzaman Chowdhury, et al.
Udgivet: (2016-08-01)

Tolerance in renal transplantation: is mixed chimerism the missing link?
af: Janes, S, et al.
Udgivet: (2009)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
af: McNeill, L, et al.
Udgivet: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
af: Tuckerman, JR, et al.
Udgivet: (2004)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
af: Mole, D, et al.
Udgivet: (2003)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
af: Schlemminger, I, et al.
Udgivet: (2003)

Studies on HIF hydroxylases
af: Webb, J
Udgivet: (2008)

Cortical dynamics subserving visual apparent motion
af: Ahmed, B, et al.
Udgivet: (2008)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
af: Holt-Martyn, JP, et al.
Udgivet: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
af: Cockman, M, et al.
Udgivet: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
af: Matthew E Cockman, et al.
Udgivet: (2019-09-01)

Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
af: Hongyan Deng, et al.
Udgivet: (2024-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
af: Chan, M, et al.
Udgivet: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
af: Yeh, TL, et al.
Udgivet: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
af: Maria Savyuk, et al.
Udgivet: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
af: Andrey A. Poloznikov, et al.
Udgivet: (2021-01-01)

The role of CCL25 and CCR9 in intestinal inflammation
af: Wendt, E, et al.
Udgivet: (2013)

Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
af: Holt-Martyn, J
Udgivet: (2018)

Adaptive changes of influenza virus A/H5N1 neuraminidase in vitro and in vivo
af: Le Nguyen, T
Udgivet: (2014)

Angiogenesis in human lung tumours
af: Ferguson, ML
Udgivet: (2008)

Editorial commentary: Understanding BCG is the key to improving it
af: McShane, H
Udgivet: (2014)

Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis
af: Hlela, C
Udgivet: (2011)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
af: Flashman, E, et al.
Udgivet: (2010)

Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury
af: Zhao-Ying Ding, et al.
Udgivet: (2022-03-01)

Probing the molecular basis of melanopsin induced light sensitivity
af: Vachtsevanos, AN
Udgivet: (2012)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
af: Chowdhury, R, et al.
Udgivet: (2013)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
af: Lippl, K
Udgivet: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
af: Masson, N, et al.
Udgivet: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
af: Takahiro Kambara, et al.
Udgivet: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
af: Kiichi Hirota
Udgivet: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
af: Kilian B. Kennel, et al.
Udgivet: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
af: Savyuk, Maria Olegovna, et al.
Udgivet: (2021-05-01)

HR23B, a biomarker for HDAC inhibitors
af: Khan, OA
Udgivet: (2013)

Risk factors for haemorrhage in patients with haematological malignancies
af: Estcourt, LJ
Udgivet: (2014)

Transcription regulation of Nrp1 during endothelial cell differentiation
af: Zhao, Z
Udgivet: (2014)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
af: Willam, C, et al.
Udgivet: (2006)

Mechanistic studies on human prolyl hydroxylase domain 2
af: Fiorini, G
Udgivet: (2024)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
af: Figg, WD, et al.
Udgivet: (2021)