Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes

<p>This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The fir...

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Bibliografische gegevens
Hoofdauteur:	Wijeyekoon, JB
Andere auteurs:	Pugh, C
Formaat:	Thesis
Taal:	English
Gepubliceerd in:	2013
Onderwerpen:	Medical Sciences Clinical laboratory sciences

Gelijkaardige items

Regulation of HIF: prolyl hydroxylases.
door: Stolze, I, et al.
Gepubliceerd in: (2006)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
door: Chowdhury, R, et al.
Gepubliceerd in: (2016)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
door: Rasheduzzaman Chowdhury, et al.
Gepubliceerd in: (2016-08-01)

Tolerance in renal transplantation: is mixed chimerism the missing link?
door: Janes, S, et al.
Gepubliceerd in: (2009)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
door: McNeill, L, et al.
Gepubliceerd in: (2002)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
door: Tuckerman, JR, et al.
Gepubliceerd in: (2004)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
door: Mole, D, et al.
Gepubliceerd in: (2003)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
door: Schlemminger, I, et al.
Gepubliceerd in: (2003)

Studies on HIF hydroxylases
door: Webb, J
Gepubliceerd in: (2008)

Cortical dynamics subserving visual apparent motion
door: Ahmed, B, et al.
Gepubliceerd in: (2008)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
door: Holt-Martyn, JP, et al.
Gepubliceerd in: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
door: Cockman, M, et al.
Gepubliceerd in: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
door: Matthew E Cockman, et al.
Gepubliceerd in: (2019-09-01)

Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners
door: Hongyan Deng, et al.
Gepubliceerd in: (2024-06-01)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
door: Chan, M, et al.
Gepubliceerd in: (2016)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
door: Yeh, TL, et al.
Gepubliceerd in: (2017)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
door: Maria Savyuk, et al.
Gepubliceerd in: (2020-07-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
door: Andrey A. Poloznikov, et al.
Gepubliceerd in: (2021-01-01)

The role of CCL25 and CCR9 in intestinal inflammation
door: Wendt, E, et al.
Gepubliceerd in: (2013)

Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
door: Holt-Martyn, J
Gepubliceerd in: (2018)

Adaptive changes of influenza virus A/H5N1 neuraminidase in vitro and in vivo
door: Le Nguyen, T
Gepubliceerd in: (2014)

Angiogenesis in human lung tumours
door: Ferguson, ML
Gepubliceerd in: (2008)

Editorial commentary: Understanding BCG is the key to improving it
door: McShane, H
Gepubliceerd in: (2014)

Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis
door: Hlela, C
Gepubliceerd in: (2011)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
door: Flashman, E, et al.
Gepubliceerd in: (2010)

Therapeutic Effect of Extracellular Vesicles Derived from HIF Prolyl Hydroxylase Domain Enzyme Inhibitor-Treated Cells on Renal Ischemia/Reperfusion Injury
door: Zhao-Ying Ding, et al.
Gepubliceerd in: (2022-03-01)

Probing the molecular basis of melanopsin induced light sensitivity
door: Vachtsevanos, AN
Gepubliceerd in: (2012)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
door: Chowdhury, R, et al.
Gepubliceerd in: (2013)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
door: Lippl, K
Gepubliceerd in: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
door: Masson, N, et al.
Gepubliceerd in: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
door: Takahiro Kambara, et al.
Gepubliceerd in: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
door: Kiichi Hirota
Gepubliceerd in: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
door: Kilian B. Kennel, et al.
Gepubliceerd in: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
door: Savyuk, Maria Olegovna, et al.
Gepubliceerd in: (2021-05-01)

HR23B, a biomarker for HDAC inhibitors
door: Khan, OA
Gepubliceerd in: (2013)

Risk factors for haemorrhage in patients with haematological malignancies
door: Estcourt, LJ
Gepubliceerd in: (2014)

Transcription regulation of Nrp1 during endothelial cell differentiation
door: Zhao, Z
Gepubliceerd in: (2014)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
door: Willam, C, et al.
Gepubliceerd in: (2006)

Mechanistic studies on human prolyl hydroxylase domain 2
door: Fiorini, G
Gepubliceerd in: (2024)

Structural basis of prolyl hydroxylase domain inhibition by Molidustat
door: Figg, WD, et al.
Gepubliceerd in: (2021)