CDC4/FBXW7 and the 'just enough' model of tumourigenesis

CDC4/FBXW7 and the 'just enough' model of tumourigenesis

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There is good evidence to show that cancer-causing mutations are not always simple gain- and loss-of-function changes. One example is the APC gene, where the combination of mutations produces a 'just-right' level of Wnt signalling. A recent article by Berger and colleagues posited a '...

書誌詳細
主要な著者:	Davis, H, Tomlinson, I
フォーマット:	Journal article
言語:	English
出版事項:	2012

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