HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

<p>Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA <em>HOTAIR</em> (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte development. We find...

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Detalhes bibliográficos
Main Authors: Kuo, F-C, Neville, MJ, Sabaratnam, R, Wesolowska-Andersen, A, Phillips, D, Wittemans, LBL, van Dam, AD, Loh, NY, Todorčević, M, Denton, N, Kentistou, KA, Joshi, PK, Christodoulides, C, Langenberg, C, Collas, P, Karpe, F, Pinnick, KE
Formato: Journal article
Idioma:English
Publicado em: Cell Press 2022

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