Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.

BACKGROUND: Germ-line mutations in the base-excision-repair gene MYH have been associated with recessive inheritance of multiple colorectal adenomas. Tumors from affected persons displayed excess somatic transversions of a guanine-cytosine pair to a thymine-adenine pair (G:C-->T:A) in the AP...

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Bibliographic Details
Main Authors:	Sieber, O, Lipton, L, Crabtree, M, Heinimann, K, Fidalgo, P, Phillips, R, Bisgaard, M, Orntoft, T, Aaltonen, L, Hodgson, S, Thomas, H, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2003

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