Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis
Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...
| Główni autorzy: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Język: | English |
| Wydane: |
2008
|
| Hasła przedmiotowe: |