Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.
CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 c...
Main Authors: | , , , , , , , , , , , , , |
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格式: | Journal article |
语言: | English |
出版: |
2007
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