Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma
The intra-tumour microenvironment generates phenotypically distinct but inter-convertible malignant cell subpopulations that fuel metastatic spread and therapeutic-resistance. Whether different microenvironmental cues impose invasive or therapy-resistant phenotypes via a common mechanism is unknown....
Main Authors: | Falletta, P, Sanchez-del-Campo, L, Chauhan, J, Effern, M, Kenyon, A, Kershaw, C, Siddaway, R, Lisle, R, Freter, R, Daniels, M, Lu, X, Tüting, T, Middleton, M, Buffa, F, Willis, A, Pavitt, G, Ronai, Z, Sauka-Spengler, T, Hölzel, M, Goding, C |
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פורמט: | Journal article |
יצא לאור: |
Cold Spring Harbor Laboratory Press
2017
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