The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

<p>DNA is wrapped around proteins called histones, whose modification regulates numerous cellular processes. Therefore it is not surprising that mutations in the genes that modify the histones are frequently associated with human cancer. For example, mutations in <em>SETD2</em>, en...

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Bibliografiske detaljer
Hovedforfatter:	Pfister, SX
Andre forfattere:	Humphrey, T
Format:	Thesis
Sprog:	English
Udgivet:	2014
Fag:	Radiation Biology (medical sciences) Medical Sciences DNA damage signalling Oncology Tumours

Lignende værker

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Therapeutic targeting of histone H3 lysine 36 trimethylation-deficient cancers
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Targeting PDK and PARP to improve radiation response in preclinical models of non-small cell lung cancer
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Development of models and methods to assess the efficacy of anti-cancer drugs targeted to the mitochondria
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