The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

The three methyls: the function and therapeutic potential of histone H3K36 trimethylation

<p>DNA is wrapped around proteins called histones, whose modification regulates numerous cellular processes. Therefore it is not surprising that mutations in the genes that modify the histones are frequently associated with human cancer. For example, mutations in <em>SETD2</em>, en...

書誌詳細
第一著者:	Pfister, SX
その他の著者:	Humphrey, T
フォーマット:	学位論文
言語:	English
出版事項:	2014
主題:	Radiation Biology (medical sciences) Medical Sciences DNA damage signalling Oncology Tumours

類似資料

Selective targeting of homologous recombination deficiency
著者:: Zimmer, J
出版事項: (2014)

Real-time studies of DNA repair kinetics following low-LET short-pulse electron radiation
著者:: Mendes de Oliveira Martins, CD
出版事項: (2014)

Development of clinical biomarkers of DNA double strand breaks for cancer care
著者:: Shah, K
出版事項: (2012)

The role of Wee1 in the hypoxia-induced DNA damage response and its potential as a therapeutic target
著者:: O'Brien, EM
出版事項: (2012)

Novel regulation of SRC family kinase signalling by RASSF1 isoforms
著者:: Scrace, SF
出版事項: (2013)

The role of ubiquitylation in regulating apurinic/apyrimidinic endonuclease 1
著者:: Meisenberg, C
出版事項: (2012)

MiR-215 regulates differentiation in colorectal cancer stem cells
著者:: Jones, M
出版事項: (2014)

Impact of TMPRSS2-ERG fusion gene on prostate cancer cell response to chemotherapy, radiotherapy and androgen deprivation therapy
著者:: Ovtcharov, S
出版事項: (2015)

Base excision repair of radiation-induced DNA damage in mammalian cells
著者:: Cooper, S, 等
出版事項: (2013)

Development of bioreductive inhibitors of checkpoint kinase 1 to target hypoxic tumours
著者:: Körner, C
出版事項: (2015)

The role of LATS1 in DNA damage signalling
著者:: Latusek, R
出版事項: (2012)

Hypoxia-induced chromatin changes and ATM signalling
著者:: Olcina del Molino, M
出版事項: (2014)

An analysis of the S. cerevisiae RMI1 gene
著者:: Ashton, TM
出版事項: (2010)

The role of p53 in hypoxia-induced apoptosis
著者:: Poole, R
出版事項: (2010)

The identification and validation of Auger electron-emitting radiopharmaceuticals targeting telomerase for cancer therapy
著者:: Jackson, M
出版事項: (2013)

Targeting EGFR signalling pathway in triple negative breast cancer
著者:: Albukhari, A
出版事項: (2014)

Targeting EGFR signalling pathway in triple negative breast cancer
著者:: Albukhari, A
出版事項: (2014)

Tumour-stroma interaction in pancreatic cancer
著者:: Lunardi, S
出版事項: (2013)

Characterising the role of circulating immune cells in brain metastasis
著者:: Balathasan, L
出版事項: (2012)

Therapeutic targeting of histone H3 lysine 36 trimethylation-deficient cancers
著者:: Lopez, K
出版事項: (2019)

Novel signalling pathways regulating epithelial-mesenchymal transition in bone metastatic prostate cancer
著者:: Rao, SR
出版事項: (2014)

Combining regulatory angiogenic gene therapy and virotherapy for the treatment of breast cancer
著者:: Bazan Peregrino, M
出版事項: (2007)

Modulating the immune system by amino acid depletion - IDO and beyond
著者:: Vallius, L
出版事項: (2011)

The role of nitric oxide as a hypoxic cell radiosensitizer
著者:: Folkes, L
出版事項: (2013)

The role of ATF4 in hypoxia-induced cell death in cancer
著者:: Pike, L, 等
出版事項: (2011)

Managing melanoma in the era of personalised therapy: more than one disease
著者:: Rughani, M, 等
出版事項: (2012)

The role of host microenvironment in the pathogenesis of multiple myeloma
著者:: Lwin, STS
出版事項: (2014)

Investigating a role of ASPP2 in the cellular response to infection
著者:: Lim, Y, 等
出版事項: (2014)

Investigating the role of DNA double strand break repair in determining sensitivity to radiotherapy fraction size
著者:: Somaiah, N
出版事項: (2014)

Targeting PDK and PARP to improve radiation response in preclinical models of non-small cell lung cancer
著者:: Verbiest, T
出版事項: (2013)

Development of models and methods to assess the efficacy of anti-cancer drugs targeted to the mitochondria
著者:: Potter, M
出版事項: (2014)

Improving intraperitoneal adenovirus virotherapy for ovarian cancer
著者:: Thoma, CMM
出版事項: (2011)

The role of DLL4-NOTCH signalling in endothelial cell metabolism
著者:: Harjes, U
出版事項: (2014)

Investigation into the regulatory mechanism of BRCA2 stability
著者:: Gruber, C
出版事項: (2013)

Mitochondrial modulators of hypoxia-related pathways in tumours
著者:: Snell, CE
出版事項: (2013)

DNA damage responses to loss of telomere integrity
著者:: Carlos, AR
出版事項: (2013)

HR23B, a biomarker for HDAC inhibitors
著者:: Khan, OA
出版事項: (2013)

Arginine methylation in the E2F1 pathway
著者:: Zheng, S
出版事項: (2013)

The role of HER4 in relation to trastuzumab resistance and prognosis in HER2 positive breast cancer
著者:: Mohd Nafi, SN
出版事項: (2014)

Regulation of stemness and differentiation in colorectal cancer
著者:: Gandhi, S
出版事項: (2010)