Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping
Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-dimensional structures of protein targets that became available, mainly through X-ray crystal structure analysis, assisted by the development of synchrotron radiation sources. Structures of known drugs or inhibit...
| المؤلفون الرئيسيون: | , , , , , , , , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Royal Society
2019
|