The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.

The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.

BACKGROUND: Urokinase-type plasminogen activator (u-PA) promotes fibrinolysis by catalyzing the conversion of plasminogen to the active protease plasmin via the cleavage of a peptide bond. When localized to the external cell surface it contributes to tissue remodelling and cellular migration; inhibi...

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Detalles Bibliográficos
Main Authors: Spraggon, G, Phillips, C, Nowak, UK, Ponting, C, Saunders, D, Dobson, C, Stuart, D, Jones, E
Formato: Journal article
Idioma:English
Publicado: 1995

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