Functional dissection of a single enhancer at the mouse α-globin locus

Functional dissection of a single enhancer at the mouse α-globin locus

<p>Enhancers are cis-regulatory DNA elements that bind transcription factors and drive expression of target genes in a spatio-temporal manner. Despite their collective importance in cell fate specification, up to now enhancers have often been studied in assays that ignore the chromosomal conte...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Francis, H
Awduron Eraill:	Kassouf, M
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2019

Eitemau Tebyg

Genetic dissection of the α-globin super-enhancer in vivo
gan: Hay, D, et al.
Cyhoeddwyd: (2016)

The mouse alpha-globin locus regulatory element.
gan: Gourdon, G, et al.
Cyhoeddwyd: (1995)

Understanding fundamental principles of enhancer biology at a model locus: analysing the structure and function of an enhancer cluster at the α-globin locus
gan: Kassouf, M, et al.
Cyhoeddwyd: (2023)

Analysis of a gain-of-function mutation that produces a new transcriptional unit in the α-globin locus
gan: Bozhilov, Y
Cyhoeddwyd: (2017)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
gan: Hughes, J, et al.
Cyhoeddwyd: (2013)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
gan: Hughes, J, et al.
Cyhoeddwyd: (2013)

DNA looping in the alpha-globin locus
gan: Canals-Hamann, A, et al.
Cyhoeddwyd: (2007)

A dual reporter mouse model of the human β-globin locus: applications and limitations.
gan: Petros Papadopoulos, et al.
Cyhoeddwyd: (2012-01-01)

Structure and evolution of the horse zeta globin locus.
gan: Flint, J, et al.
Cyhoeddwyd: (1988)

Loss of balancing selection in the βS globin locus
gan: Ishag Hani B, et al.
Cyhoeddwyd: (2010-02-01)

Intergenic transcription and transinduction of the human beta-globin locus.
gan: Ashe, H, et al.
Cyhoeddwyd: (1997)

Life cycle of an n-globin pseudogene microsatellite locus
gan: Jasmin H Bavarva, et al.
Cyhoeddwyd: (2013-12-01)

Identification of four novel large deletions and complex variants in the α-globin locus in Chinese population
gan: Xiuqin Bao, et al.
Cyhoeddwyd: (2023-04-01)

The α-globin super-enhancer acts in an orientation-dependent manner
gan: Mira T. Kassouf, et al.
Cyhoeddwyd: (2025-01-01)

The α-globin super-enhancer acts in an orientation-dependent manner
gan: Kassouf, MT, et al.
Cyhoeddwyd: (2025)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
gan: Oudelaar, A, et al.
Cyhoeddwyd: (2019)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
gan: A. Marieke Oudelaar, et al.
Cyhoeddwyd: (2019-11-01)

Allelic sequence diversity at the human beta-globin locus
gan: Fullerton, S, et al.
Cyhoeddwyd: (1994)

Controlling α-globin: a review of α-globin expression and its impact on β-thalassemia
gan: Hsiao Phin Joanna Voon, et al.
Cyhoeddwyd: (2008-12-01)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
gan: Funnell, A, et al.
Cyhoeddwyd: (2014)

Impact of annotation error in α-globin genes on molecular diagnosis.
gan: J Francis Borgio
Cyhoeddwyd: (2017-01-01)

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus
gan: Rebecca S. McGreal-Estrada, et al.
Cyhoeddwyd: (2018-12-01)

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.
gan: Fullerton, J, et al.
Cyhoeddwyd: (2008)

The phenomena of balanced effect between α-globin gene and of β-globin gene
gan: Liangying Zhong, et al.
Cyhoeddwyd: (2018-08-01)

Definition of transcriptional promoters in the human beta globin locus control region.
gan: Routledge, S, et al.
Cyhoeddwyd: (2002)

Variants in the β-globin locus are associated with pneumonia in African American children
gan: Nadine L.N. Halligan, et al.
Cyhoeddwyd: (2025-01-01)

5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.
gan: Ping Kei Chan, et al.
Cyhoeddwyd: (2008-01-01)

Redox-Regulation of α-Globin in Vascular Physiology
gan: Laurent Kiger, et al.
Cyhoeddwyd: (2022-01-01)

Correlation between Plasma Interleukin-3, the α/β Globin Ratio, and Globin mRNA Stability
gan: S. Rouhi Dehnabeh, et al.
Cyhoeddwyd: (2014-01-01)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
gan: Higgs, D, et al.
Cyhoeddwyd: (1986)

Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in China
gan: Yan Yuan, et al.
Cyhoeddwyd: (2023-03-01)

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences
gan: Richard A. Morgan, et al.
Cyhoeddwyd: (2020-06-01)

Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.
gan: Imam, A, et al.
Cyhoeddwyd: (2000)

The globin switch at the level of mRNA in the developing mouse.
gan: Whitelaw, E, et al.
Cyhoeddwyd: (1989)

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia
gan: Mettananda, S, et al.
Cyhoeddwyd: (2019)

The evolution of the α- and β-globin gene clusters in human populations
gan: Hill, A, et al.
Cyhoeddwyd: (1986)

Ameliorating β-thalassaemia by manipulating expression of the α-globin gene
gan: Mettananda, S
Cyhoeddwyd: (2015)

Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
gan: Joanne Miles, et al.
Cyhoeddwyd: (2007-07-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
gan: Sachith Mettananda, et al.
Cyhoeddwyd: (2017-09-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
gan: Mettananda, S, et al.
Cyhoeddwyd: (2017)