Functional dissection of a single enhancer at the mouse α-globin locus

Functional dissection of a single enhancer at the mouse α-globin locus

<p>Enhancers are cis-regulatory DNA elements that bind transcription factors and drive expression of target genes in a spatio-temporal manner. Despite their collective importance in cell fate specification, up to now enhancers have often been studied in assays that ignore the chromosomal conte...

Полное описание

Библиографические подробности
Главный автор:	Francis, H
Другие авторы:	Kassouf, M
Формат:	Диссертация
Язык:	English
Опубликовано:	2019

Схожие документы

Genetic dissection of the α-globin super-enhancer in vivo
по: Hay, D, и др.
Опубликовано: (2016)

The mouse alpha-globin locus regulatory element.
по: Gourdon, G, и др.
Опубликовано: (1995)

Understanding fundamental principles of enhancer biology at a model locus: analysing the structure and function of an enhancer cluster at the α-globin locus
по: Kassouf, M, и др.
Опубликовано: (2023)

Analysis of a gain-of-function mutation that produces a new transcriptional unit in the α-globin locus
по: Bozhilov, Y
Опубликовано: (2017)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
по: Hughes, J, и др.
Опубликовано: (2013)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
по: Hughes, J, и др.
Опубликовано: (2013)

DNA looping in the alpha-globin locus
по: Canals-Hamann, A, и др.
Опубликовано: (2007)

A dual reporter mouse model of the human β-globin locus: applications and limitations.
по: Petros Papadopoulos, и др.
Опубликовано: (2012-01-01)

Structure and evolution of the horse zeta globin locus.
по: Flint, J, и др.
Опубликовано: (1988)

Loss of balancing selection in the βS globin locus
по: Ishag Hani B, и др.
Опубликовано: (2010-02-01)

Intergenic transcription and transinduction of the human beta-globin locus.
по: Ashe, H, и др.
Опубликовано: (1997)

Life cycle of an n-globin pseudogene microsatellite locus
по: Jasmin H Bavarva, и др.
Опубликовано: (2013-12-01)

Identification of four novel large deletions and complex variants in the α-globin locus in Chinese population
по: Xiuqin Bao, и др.
Опубликовано: (2023-04-01)

The α-globin super-enhancer acts in an orientation-dependent manner
по: Mira T. Kassouf, и др.
Опубликовано: (2025-01-01)

The α-globin super-enhancer acts in an orientation-dependent manner
по: Kassouf, MT, и др.
Опубликовано: (2025)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
по: Oudelaar, A, и др.
Опубликовано: (2019)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
по: A. Marieke Oudelaar, и др.
Опубликовано: (2019-11-01)

Allelic sequence diversity at the human beta-globin locus
по: Fullerton, S, и др.
Опубликовано: (1994)

Controlling α-globin: a review of α-globin expression and its impact on β-thalassemia
по: Hsiao Phin Joanna Voon, и др.
Опубликовано: (2008-12-01)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
по: Funnell, A, и др.
Опубликовано: (2014)

Impact of annotation error in α-globin genes on molecular diagnosis.
по: J Francis Borgio
Опубликовано: (2017-01-01)

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus
по: Rebecca S. McGreal-Estrada, и др.
Опубликовано: (2018-12-01)

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.
по: Fullerton, J, и др.
Опубликовано: (2008)

The phenomena of balanced effect between α-globin gene and of β-globin gene
по: Liangying Zhong, и др.
Опубликовано: (2018-08-01)

Definition of transcriptional promoters in the human beta globin locus control region.
по: Routledge, S, и др.
Опубликовано: (2002)

Variants in the β-globin locus are associated with pneumonia in African American children
по: Nadine L.N. Halligan, и др.
Опубликовано: (2025-01-01)

5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.
по: Ping Kei Chan, и др.
Опубликовано: (2008-01-01)

Redox-Regulation of α-Globin in Vascular Physiology
по: Laurent Kiger, и др.
Опубликовано: (2022-01-01)

Correlation between Plasma Interleukin-3, the α/β Globin Ratio, and Globin mRNA Stability
по: S. Rouhi Dehnabeh, и др.
Опубликовано: (2014-01-01)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
по: Higgs, D, и др.
Опубликовано: (1986)

Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in China
по: Yan Yuan, и др.
Опубликовано: (2023-03-01)

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences
по: Richard A. Morgan, и др.
Опубликовано: (2020-06-01)

Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.
по: Imam, A, и др.
Опубликовано: (2000)

The globin switch at the level of mRNA in the developing mouse.
по: Whitelaw, E, и др.
Опубликовано: (1989)

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia
по: Mettananda, S, и др.
Опубликовано: (2019)

The evolution of the α- and β-globin gene clusters in human populations
по: Hill, A, и др.
Опубликовано: (1986)

Ameliorating β-thalassaemia by manipulating expression of the α-globin gene
по: Mettananda, S
Опубликовано: (2015)

Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
по: Joanne Miles, и др.
Опубликовано: (2007-07-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
по: Sachith Mettananda, и др.
Опубликовано: (2017-09-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
по: Mettananda, S, и др.
Опубликовано: (2017)