Functional dissection of a single enhancer at the mouse α-globin locus

Functional dissection of a single enhancer at the mouse α-globin locus

<p>Enhancers are cis-regulatory DNA elements that bind transcription factors and drive expression of target genes in a spatio-temporal manner. Despite their collective importance in cell fate specification, up to now enhancers have often been studied in assays that ignore the chromosomal conte...

书目详细资料
主要作者:	Francis, H
其他作者:	Kassouf, M
格式:	Thesis
语言:	English
出版:	2019

相似书籍

Genetic dissection of the α-globin super-enhancer in vivo
由: Hay, D, et al.
出版: (2016)

The mouse alpha-globin locus regulatory element.
由: Gourdon, G, et al.
出版: (1995)

Understanding fundamental principles of enhancer biology at a model locus: analysing the structure and function of an enhancer cluster at the α-globin locus
由: Kassouf, M, et al.
出版: (2023)

Analysis of a gain-of-function mutation that produces a new transcriptional unit in the α-globin locus
由: Bozhilov, Y
出版: (2017)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
由: Hughes, J, et al.
出版: (2013)

High-resolution analysis of cis-acting regulatory networks at the α-globin locus.
由: Hughes, J, et al.
出版: (2013)

DNA looping in the alpha-globin locus
由: Canals-Hamann, A, et al.
出版: (2007)

A dual reporter mouse model of the human β-globin locus: applications and limitations.
由: Petros Papadopoulos, et al.
出版: (2012-01-01)

Structure and evolution of the horse zeta globin locus.
由: Flint, J, et al.
出版: (1988)

Loss of balancing selection in the βS globin locus
由: Ishag Hani B, et al.
出版: (2010-02-01)

Intergenic transcription and transinduction of the human beta-globin locus.
由: Ashe, H, et al.
出版: (1997)

Life cycle of an n-globin pseudogene microsatellite locus
由: Jasmin H Bavarva, et al.
出版: (2013-12-01)

Identification of four novel large deletions and complex variants in the α-globin locus in Chinese population
由: Xiuqin Bao, et al.
出版: (2023-04-01)

The α-globin super-enhancer acts in an orientation-dependent manner
由: Mira T. Kassouf, et al.
出版: (2025-01-01)

The α-globin super-enhancer acts in an orientation-dependent manner
由: Kassouf, MT, et al.
出版: (2025)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
由: Oudelaar, A, et al.
出版: (2019)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
由: A. Marieke Oudelaar, et al.
出版: (2019-11-01)

Allelic sequence diversity at the human beta-globin locus
由: Fullerton, S, et al.
出版: (1994)

Controlling α-globin: a review of α-globin expression and its impact on β-thalassemia
由: Hsiao Phin Joanna Voon, et al.
出版: (2008-12-01)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
由: Funnell, A, et al.
出版: (2014)

Impact of annotation error in α-globin genes on molecular diagnosis.
由: J Francis Borgio
出版: (2017-01-01)

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus
由: Rebecca S. McGreal-Estrada, et al.
出版: (2018-12-01)

Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus.
由: Fullerton, J, et al.
出版: (2008)

The phenomena of balanced effect between α-globin gene and of β-globin gene
由: Liangying Zhong, et al.
出版: (2018-08-01)

Definition of transcriptional promoters in the human beta globin locus control region.
由: Routledge, S, et al.
出版: (2002)

Variants in the β-globin locus are associated with pneumonia in African American children
由: Nadine L.N. Halligan, et al.
出版: (2025-01-01)

5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.
由: Ping Kei Chan, et al.
出版: (2008-01-01)

Redox-Regulation of α-Globin in Vascular Physiology
由: Laurent Kiger, et al.
出版: (2022-01-01)

Correlation between Plasma Interleukin-3, the α/β Globin Ratio, and Globin mRNA Stability
由: S. Rouhi Dehnabeh, et al.
出版: (2014-01-01)

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.
由: Higgs, D, et al.
出版: (1986)

Case report: Long-read sequencing identified a novel 14.9-kb deletion of the α-globin gene locus in a family with α-thalassemia in China
由: Yan Yuan, et al.
出版: (2023-03-01)

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences
由: Richard A. Morgan, et al.
出版: (2020-06-01)

Modification of human beta-globin locus PAC clones by homologous recombination in Escherichia coli.
由: Imam, A, et al.
出版: (2000)

The globin switch at the level of mRNA in the developing mouse.
由: Whitelaw, E, et al.
出版: (1989)

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia
由: Mettananda, S, et al.
出版: (2019)

The evolution of the α- and β-globin gene clusters in human populations
由: Hill, A, et al.
出版: (1986)

Ameliorating β-thalassaemia by manipulating expression of the α-globin gene
由: Mettananda, S
出版: (2015)

Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
由: Joanne Miles, et al.
出版: (2007-07-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
由: Sachith Mettananda, et al.
出版: (2017-09-01)

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia
由: Mettananda, S, et al.
出版: (2017)