Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.

Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.

In a previous study we isolated a series of rat monoclonal antibodies to the human leukocyte common (LC) antigen and demonstrated that synergistic complement lysis was possible between IgG2b antibodies which recognised different epitopes. In this report we have examined the mechanisms that were invo...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Bindon, C, Hale, G, Hughes-Jones, N, Gorick, B, Waldmann, H
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	1987

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Therapeutic potential of monoclonal antibodies to the leukocyte-common antigen. Synergy and interference in complement-mediated lysis.
nork: Bindon, C, et al.
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Importance of antigen specificity for complement-mediated lysis by monoclonal antibodies.
nork: Bindon, C, et al.
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Therapeutic potential of monoclonal antibodies to the leucocyte common antigen.
nork: Bindon, C, et al.
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Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.
nork: Xia, M, et al.
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Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q.
nork: Bindon, C, et al.
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nork: Xia, M, et al.
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nork: Tighe, H, et al.
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nork: Bindon, C, et al.
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nork: Kandis Wright, et al.
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Monoclonal antibodies to rat leukocyte surface antigens, MHC antigens, and immunoglobulins.
nork: Puklavec, M, et al.
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Monoclonal antibodies against rat leukocyte surface antigens.
nork: van den Berg, T, et al.
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RAT MONOCLONAL-ANTIBODIES FOR BONE-MARROW TRANSPLANTATION (BMT) - THE CAMPATH SERIES
nork: Waldmann, H, et al.
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nork: Cobbold, S, et al.
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nork: Cobbold, S, et al.
Argitaratua: (1990)

Monoclonal antibodies for immunosuppression.
nork: Waldmann, H, et al.
Argitaratua: (1988)

Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.
nork: Greenwood, J, et al.
Argitaratua: (1994)

COMPLEMENT LYSIS MEDIATED BY ENGINEERED MULTIPLE-DOMAIN FORMS OF THE THERAPEUTIC ANTIBODY CAMPATH-1H
nork: Greenwood, J, et al.
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nork: Waldmann, H, et al.
Argitaratua: (1986)

Pilot study of CAMPATH-1, a rat monoclonal antibody that fixes human complement, as an immunosuppressant in organ transplantation.
nork: Hale, G, et al.
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nork: Clark, M, et al.
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nork: Dyer, M, et al.
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nork: Clark, M, et al.
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nork: Hale, G, et al.
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nork: Tam, S, et al.
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nork: Brons, I, et al.
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nork: Gabriel B. Correa, et al.
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Monoclonal antibodies that define canine homologues of human CD antigens: summary of the First International Canine Leukocyte Antigen Workshop (CLAW).
nork: Cobbold, S, et al.
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nork: David A. Spencer, et al.
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Advantages of rat monoclonal antibodies.
nork: Clark, M, et al.
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Specificity of monoclonal antibody Campath-1.
nork: Hale, G, et al.
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