Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.

Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.

Dehydroquinate synthase (DHQS) has long been regarded as a catalytic marvel because of its ability to perform several consecutive chemical reactions in one active site. There has been considerable debate as to whether DHQS is actively involved in all these steps, or whether several steps occur spont...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Carpenter, E, Hawkins, A, Frost, J, Brown, K
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	1998

Παρόμοια τεκμήρια

Multistep catalysis dehydroquinate synthase.
ανά: Brown, K, κ.ά.
Έκδοση: (2000)

Identification of many crystal forms of Aspergillus nidulans dehydroquinate synthase.
ανά: Nichols, C, κ.ά.
Έκδοση: (2001)

Biophysical and kinetic analysis of wild-type and site-directed mutants of the isolated and native dehydroquinate synthase domain of the AROM protein.
ανά: Park, A, κ.ά.
Έκδοση: (2004)

Ligand-induced conformational changes and a mechanism for domain closure in Aspergillus nidulans dehydroquinate synthase.
ανά: Nichols, C, κ.ά.
Έκδοση: (2003)

Comparison of ligand-induced conformational changes and domain closure mechanisms, between prokaryotic and eukaryotic dehydroquinate synthases.
ανά: Nichols, C, κ.ά.
Έκδοση: (2004)

Structure of the 'open' form of Aspergillus nidulans 3-dehydroquinate synthase at 1.7 A resolution from crystals grown following enzyme turnover.
ανά: Nichols, C, κ.ά.
Έκδοση: (2004)

Dehydroquinate Synthase Directly Binds to Streptomycin and Regulates Susceptibility of Mycobacterium bovis to Streptomycin in a Non-canonical Mode
ανά: Wenping Wei, κ.ά.
Έκδοση: (2022-04-01)

Discovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.
ανά: Kiira Ratia, κ.ά.
Έκδοση: (2014-01-01)

Identification of mycosporinelike amino acids and 3-dehydroquinate synthase gene expression in UV radiation-induced Deinococcus radiodurans R1
ανά: Huwaidi, Alaa Hassan Ibrahim Ahmed
Έκδοση: (2018)

Structure of ATP synthase under strain during catalysis
ανά: Hui Guo, κ.ά.
Έκδοση: (2022-04-01)

Identification of polyketide inhibitors targeting 3-dehydroquinate dehydratase in the shikimate pathway of Enterococcus faecalis.
ανά: Vivian Wing Ngar Cheung, κ.ά.
Έκδοση: (2014-01-01)

Functional Analysis of 3-Dehydroquinate Dehydratase/Shikimate Dehydrogenases Involved in Shikimate Pathway in Camellia sinensis
ανά: Keyi Huang, κ.ά.
Έκδοση: (2019-10-01)

Structure, catalysis, chitin transport, and selective inhibition of chitin synthase
ανά: Dan-Dan Chen, κ.ά.
Έκδοση: (2023-08-01)

Altered Electrochemistry at Graphene- or Alumina-Modified Electrodes: Catalysis vs Electrocatalysis in Multistep Electrode Processes
ανά: Poon, J, κ.ά.
Έκδοση: (2015)

Author Correction: Structure of ATP synthase under strain during catalysis
ανά: Hui Guo, κ.ά.
Έκδοση: (2022-05-01)

The unusual bifunctional catalysis of epimerization and desaturation by carbapenem synthase.
ανά: Topf, M, κ.ά.
Έκδοση: (2004)

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase
ανά: Sing Mei Lim, κ.ά.
Έκδοση: (2013-06-01)

Murine erythroid 5‐aminolevulinate synthase: Adenosyl‐binding site Lys221 modulates substrate binding and catalysis
ανά: Bosko M. Stojanovski, κ.ά.
Έκδοση: (2015-01-01)

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
ανά: Rabe, P, κ.ά.
Έκδοση: (2021)

Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases.
ανά: Tomas Majtan, κ.ά.
Έκδοση: (2014-01-01)

Snapshots of radical enzyme catalysis : the crystal structures of biotin synthase and lysine 5,6-aminomutase
ανά: Berkovitch, Frederick, 1978-
Έκδοση: (2005)

Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis
ανά: Ronja Driller, κ.ά.
Έκδοση: (2018-09-01)

Studies on the active site of deacetoxycephalosporin C synthase.
ανά: Lloyd, MD, κ.ά.
Έκδοση: (1999)

Targeting active site residues and structural anchoring positions in terpene synthases
ανά: Anwei Hou, κ.ά.
Έκδοση: (2021-09-01)

Dynamic transformation of active sites in energy and environmental catalysis
ανά: Zhang, Hao, κ.ά.
Έκδοση: (2024)

The Molecular Design of Active Sites in Nanoporous Materials for Sustainable Catalysis
ανά: Stephanie Chapman, κ.ά.
Έκδοση: (2017-12-01)

The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.
ανά: Lipscomb, S, κ.ά.
Έκδοση: (2002)

Structure Distortion Endows Copper Nanoclusters with Surface-Active Uncoordinated Sites for Boosting Catalysis
ανά: Jing Sun, κ.ά.
Έκδοση: (2024-08-01)

Kinetics of multistep reactions /
ανά: Helfferich, Friedrich G., 1922-
Έκδοση: (2004)

A Target to Combat Antibiotic Resistance: Biochemical and Biophysical Characterization of 3-Dehydroquinate Dehydratase from Methicillin-Resistant <i>Staphylococcus aureus</i>
ανά: Alfredo Téllez-Valencia, κ.ά.
Έκδοση: (2024-11-01)

Discovery of Potential Noncovalent Inhibitors of Dehydroquinate Dehydratase from Methicillin-Resistant <i>Staphylococcus aureus</i> through Computational-Driven Drug Design
ανά: César Millán-Pacheco, κ.ά.
Έκδοση: (2023-08-01)

A multistep approach to preventing wrong site surgery in skin lesion excision
ανά: Nabil Mopuri, κ.ά.
Έκδοση: (2021-09-01)

An albumin-derived peptide scaffold capable of binding and catalysis.
ανά: Immacolata Luisi, κ.ά.
Έκδοση: (2013-01-01)

Molecular Dynamics Simulation Reveal the Structure–Activity Relationships of Kainoid Synthases
ανά: Zeyu Fan, κ.ά.
Έκδοση: (2024-07-01)

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
ανά: Chen, Dan, κ.ά.
Έκδοση: (2018)

Function of the active site lysine autoacetylation in Tip60 catalysis.
ανά: Chao Yang, κ.ά.
Έκδοση: (2012-01-01)

Site-selective modification of peptides using rhodium and palladium catalysis: complementary electrophilic and nucleophilic arylation.
ανά: Chapman, C, κ.ά.
Έκδοση: (2007)

Multistep Modelling and Monitoring of Bioprocesses
ανά: Velislava Lyubenova, κ.ά.
Έκδοση: (2024-12-01)

Multistep nucleation of anisotropic molecules
ανά: Kazuaki Z. Takahashi, κ.ά.
Έκδοση: (2021-09-01)

The multistep decomposition of boric acid
ανά: Clemens Huber, κ.ά.
Έκδοση: (2020-05-01)