The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.

The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.

The ASPP1 (Apoptosis Stimulating Protein of p53) protein is an important tumour-suppressor. We have detected a novel protein interaction between the human ASPP1 (hASPP1) protein and the predominantly nuclear adaptor protein SAM68. In the human testis, full-length endogenous hASPP1 protein is located...

書誌詳細
主要な著者:	Thornton, J, Dalgleish, C, Venables, J, Sergeant, K, Ehrmann, I, Lu, X, Saunders, P, Elliott, D
フォーマット:	Journal article
言語:	English
出版事項:	2006

類似資料

ASPP: a new family of oncogenes and tumour suppressor genes.
著者:: Sullivan, A, 等
出版事項: (2007)

The tumour suppressor ASPP2 plays a novel role in the maintenance of epithelial cell polarity
著者:: Sottocornola, R
出版事項: (2010)

Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.
著者:: Bennett, K, 等
出版事項: (1995)

Structural basis for ASPP2 recognition by the tumor suppressor p73
著者:: Canning, P, 等
出版事項: (2012)

Structural basis for ASPP2 recognition by the tumor suppressor p73.
著者:: Canning, P, 等
出版事項: (2012)

CD44 isoform expression mediated by alternative splicing: tissue-specific regulation in mice.
著者:: Hirano, H, 等
出版事項: (1994)

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.
著者:: Bennett, K, 等
出版事項: (1995)

ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.
著者:: Vives, V, 等
出版事項: (2006)

Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon.
著者:: Jackson, D, 等
出版事項: (1995)

A putative exonic splicing enhancer in exon 7 of the PDHA1 gene affects splicing of adjacent exons.
著者:: Ridout, C, 等
出版事項: (2008)

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
著者:: Slee, EA, 等
出版事項: (2004)

Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)
著者:: Vasileia Tsintari, 等
出版事項: (2022-07-01)

A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes.
著者:: Natalia N Singh, 等
出版事項: (2012-01-01)

p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
著者:: Miller, P, 等
出版事項: (2023)

Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2.
著者:: Nešić, D, 等
出版事項: (2014)

Investigating the role of iASPP and ASPP2 in human carcinoma
著者:: Salter, V
出版事項: (2014)

Effect of exonic splicing regulation on synonymous codon usage in alternatively spliced exons of <it>Dscam</it>
著者:: Takahashi Aya
出版事項: (2009-08-01)

The Landscapes of Full-Length Transcripts and Splice Isoforms as Well as Transposons Exonization in the Lepidopteran Model System, Bombyx mori
著者:: Zongrui Dai, 等
出版事項: (2021-09-01)

Universal alternative splicing of noncoding exons
著者:: Deveson, I, 等
出版事項: (2018)

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.
著者:: Aylon, Y, 等
出版事項: (2010)

Identification and Characterization of CD44RC, a Novel Alternatively Spliced Soluble CD44 Isoform that can Potentiate the Hyaluronan Binding Activity of Cell Surface CD44
著者:: Roland K. Chiu, 等
出版事項: (1999-11-01)

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.
著者:: Screaton, G, 等
出版事項: (1992)

Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation.
著者:: Ansgar Zoch, 等
出版事項: (2015-01-01)

Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology
著者:: Hammesfahr Björn, 等
出版事項: (2011-06-01)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
著者:: Lotz, R, 等
出版事項: (2025)

ASPP [corrected] and cancer.
著者:: Trigiante, G, 等
出版事項: (2006)

The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor
著者:: Danny Legge, 等
出版事項: (2022-02-01)

The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.
著者:: Yilei Liu, 等
出版事項: (2009-11-01)

ASPP1 and ASPP2: common activators of p53 family members.
著者:: Bergamaschi, D, 等
出版事項: (2004)

ASPP1 and ASPP2 are new transcriptional targets of E2F.
著者:: Fogal, V, 等
出版事項: (2005)

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
著者:: Yangfan Qi, 等
出版事項: (2016-06-01)

TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms
著者:: Lu Guo, 等
出版事項: (2022-05-01)

ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer
著者:: Anna Melekhova, 等
出版事項: (2021-09-01)

Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
著者:: Rebecca Lotz, 等
出版事項: (2025-01-01)

Alternative splicing of a single exon causes a major impact on the affinity of Caenorhabditis elegans tropomyosin isoforms for actin filaments
著者:: Shoichiro Ono, 等
出版事項: (2023-09-01)

Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.
著者:: Sushma Grellscheid, 等
出版事項: (2011-12-01)

Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1
著者:: Kay-Dietrich Wagner, 等
出版事項: (2019-01-01)

Tumour suppressors in liver carcinogenesis.
著者:: Dufour, J, 等
出版事項: (2007)

Specificity of 6th Workshop CD44 panel antibodies for alternatively spliced exons and their effects on lymphocyte activation and hyaluronan binding.
著者:: Bannerji, S, 等
出版事項: (1996)

Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers
著者:: Han Qiu, 等
出版事項: (2023-11-01)