Connective Tissue Growth Factor (CTGF) contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

Connective Tissue Growth Factor (CTGF) contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

<h4>Objectives</h4> <p>One mechanism by which cartilage responds to mechanical load is by releasing heparinbound growth factors from the pericellular matrix (PCM). By proteomic analysis of the PCM, we identified connective tissue growth factor (CTGF) and here investigate its funct...

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מידע ביבליוגרפי
Main Authors:	Tang, X, Muhammad, H, McLean, C, Zarebska, J, Fleming, J, Didangelos, A, Onnerfjord, P, Leask, A, Saklatvala, J, Vincent, T
פורמט:	Journal article
יצא לאור:	BMJ Publishing Group 2018

פריטים דומים

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Vectorial secretion of CTGF as a cell-type specific response to LPA and TGF-β in human tubular epithelial cells
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The possible interplay of mechanical and molecular factors in cartilage degeneration in osteoarthritis
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