Connective Tissue Growth Factor (CTGF) contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

Connective Tissue Growth Factor (CTGF) contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ

<h4>Objectives</h4> <p>One mechanism by which cartilage responds to mechanical load is by releasing heparinbound growth factors from the pericellular matrix (PCM). By proteomic analysis of the PCM, we identified connective tissue growth factor (CTGF) and here investigate its funct...

Bibliografiset tiedot
Päätekijät:	Tang, X, Muhammad, H, McLean, C, Zarebska, J, Fleming, J, Didangelos, A, Onnerfjord, P, Leask, A, Saklatvala, J, Vincent, T
Aineistotyyppi:	Journal article
Julkaistu:	BMJ Publishing Group 2018

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