Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.

HIV-1 often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. We used single-genome amplification and sequencing of complete HIV genomes to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral se...

詳細記述

書誌詳細
主要な著者: Ganusov, V, Goonetilleke, N, Liu, M, Ferrari, G, Shaw, G, Mcmichael, A, Borrow, P, Korber, B, Perelson, A
フォーマット: Journal article
言語:English
出版事項: 2011