Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package

Cyclin-Dependent Kinase 12 (CDK12), Human Kinase Domain; A Target Enabling Package

A description of the materials and methods is included within the TEP datasheet. Cyclin-dependent kinase 12 (CDK12) phosphorylates RNA Pol II C-terminal domain (CTD) to promote transcriptional elongation of large DNA damage response genes. CDK12 is frequently mutated or amplified in cancer and its l...

Podrobná bibliografie
Další autoři:	Bullock, A
Médium:	Dataset
Vydáno:	University of Oxford 2018
Témata:	Chemical Biology Structural Genomics Drug Discovery

Podobné jednotky

Cyclin-dependent kinase 12 (CDK12), human kinase domain; a Target Enabling Package
Autor: Dixon-Clarke, S
Vydáno: (2018)

Cyclin-Dependent Kinase 12 (CDK12), human kinase domain; A Target Enabling Package
Vydáno: (2018)

LIM domain kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
Autor: Mathea, S
Vydáno: (2018)

LIM Domain Kinase 1 (LIMK1), Human Kinase Domain; A Target Enabling Package
Autor: Bullock, A
Vydáno: (2018)

LIM Domain Kinase 1 (LIMK1), human kinase domain; A Target Enabling Package
Autor: Mathea, S
Vydáno: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
Autor: Bullock, A
Vydáno: (2018)

With no lysine kinase 3 (WNK3); A Target Enabling Package
Autor: Pinkas, D
Vydáno: (2018)

With No Lysine Kinase 3 (WNK3); A Target Enabling Package
Autor: Pinkas, D
Vydáno: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
Autor: Cox, O
Vydáno: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
Autor: Cox, O
Vydáno: (2018)

Pleckstrin Homology Domain Interacting Protein (PHIP); A Target Enabling Package
Autor: Brennan, P
Vydáno: (2018)

Human RECQL5 Helicase; A Target Enabling Package
Autor: Gileadi, O
Vydáno: (2018)

Human RECQL5 Helicase; A Target Enabling Package
Autor: Newman, J
Vydáno: (2018)

Human RECQL5 Helicase; A Target Enabling Package
Autor: Newman, J
Vydáno: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
Vydáno: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
Autor: Kopec, J
Vydáno: (2018)

Human alpha-aminoadipic semialdehyde synthase (AASS); A Target Enabling Package
Autor: Yue, W
Vydáno: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
Autor: Brennan, P
Vydáno: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Autor: Brennan, P
Vydáno: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
Autor: Savitsky, P
Vydáno: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Autor: Brennan, P
Vydáno: (2018)

Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
Autor: Brennan, P
Vydáno: (2018)

Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Autor: Savitsky, P
Vydáno: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
Autor: Carpenter, E
Vydáno: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
Autor: Chu, A
Vydáno: (2018)

Dolichyl-Phosphate Alpha-N-Acetyl Glucosaminyl Transferase (DPAGT1); A Target Enabling Package
Autor: Dong, Y
Vydáno: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
Autor: Newman, J
Vydáno: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
Autor: Gileadi, O
Vydáno: (2018)

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package
Autor: Newman, J
Vydáno: (2018)

Meiotic regulation of cyclin-dependent kinases
Autor: Miller, Matthew P., Ph. D. (Matthew Paul). Massachusetts Institute of Technology
Vydáno: (2013)

Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei.
Autor: Séverine Monnerat, a další
Vydáno: (2013-01-01)

Cyclin-dependent kinase (CDK) 4/6 inhibitors in oncology
Autor: Karamitrousis Evangelos, a další
Vydáno: (2020-04-01)

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning
Autor: Gabriella O Estevam, a další
Vydáno: (2025-02-01)

Cyclin-Dependent Kinase regulation and function during meiosis
Autor: Carlile, Thomas M. (Thomas Marshal), Jr
Vydáno: (2010)

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
Autor: Andrea Brenna, a další
Vydáno: (2019-11-01)

Cyclin‐dependent kinase 12‐mediated super‐enhancers as promising targets in cancer therapy
Autor: Fuda Xie, a další
Vydáno: (2022-12-01)

Functional characterization of the cyclin-dependent kinase inhibitor p21 by gene targeting in the mouse
Autor: Brugarolas, James (James Burfau), 1969-
Vydáno: (2009)

Cyclin K goes with Cdk12 and Cdk13
Autor: Kohoutek Jiri, a další
Vydáno: (2012-04-01)

Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation
Autor: Aymen al-Rawi, a další
Vydáno: (2023-03-01)

The awakening of the CDK10/Cyclin M protein kinase
Autor: Gamble, Carly, a další
Vydáno: (2017)