Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes
A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals. This occludes blood flow, leads to inflammation, and increases parasitemia by reducing spleen-mediated clearance of...
Main Authors: | Lennartz, F, Smith, C, Craig, A, Higgins, M |
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格式: | Journal article |
語言: | English |
出版: |
National Academy of Sciences
2019
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