Mechanistic and inhibition studies on isocitrate dehydrogenase 1

Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

書誌詳細
第一著者:	Liu, S
その他の著者:	Schofield, C
フォーマット:	学位論文
言語:	English
出版事項:	2019

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