Mechanistic and inhibition studies on isocitrate dehydrogenase 1

Mechanistic and inhibition studies on isocitrate dehydrogenase 1

<p>Genes encoding for IDH1 and IDH2 are frequently mutated in multiple cancer types including gliomas and AML. IDH variants, notably R132H IDH1, result in a gain-offunction leading to substantially enhanced production of the ‘oncometabolite’, 2- hydroxyglutarate. Drug development by pharmaceut...

Полное описание

Библиографические подробности
Главный автор:	Liu, S
Другие авторы:	Schofield, C
Формат:	Диссертация
Язык:	English
Опубликовано:	2019

Схожие документы

The studies on the mechanism and inhibition of Isocitrate Dehydrogenases
по: Liu, X
Опубликовано: (2022)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
по: Li Su, и др.
Опубликовано: (2020-04-01)

How robust are the data in vorasidenib for isocitrate dehydrogenase-1 or isocitrate dehydrogenase-2 mutant low-grade glioma?
по: Eric T Wong
Опубликовано: (2023-01-01)

Highlighting the mechanistic role of Olutasidenib (FT-2102) in the selective inhibition of mutated isocitrate dehydrogenase 1 (mIDH1) in cancer therapy
по: Elliasu Y. Salifu, и др.
Опубликовано: (2022-01-01)

Differentiating inhibition selectivity and binding affinity of isocitrate dehydrogenase 1 variant inhibitors
по: Liu, S, и др.
Опубликовано: (2023)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
по: Liu, S, и др.
Опубликовано: (2021)

Inhibitors of mutant isocitrate dehydrogenase for isocitrate dehydrogenase-mutant gliomas: A new standard of care?
по: Emilie Le Rhun, и др.
Опубликовано: (2024-01-01)

Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
по: Shuang Liu, и др.
Опубликовано: (2021-11-01)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
по: Yang Liu, и др.
Опубликовано: (2023-04-01)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
по: Xiaoyan Liu, и др.
Опубликовано: (2019-10-01)

Studies on human cancer variant and mycobacterial isocitrate dehydrogenases
по: Reinbold, R
Опубликовано: (2021)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
по: Tomoaki Ishida, и др.
Опубликовано: (2021-12-01)

Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients
по: Emre LEVENTOGLU, и др.
Опубликовано: (2023-06-01)

Mutasi Isocitrate Dehydrogenase 1 dan 2 pada Glioma
по: Ni Putu Sriwidyani
Опубликовано: (2020-12-01)

Functional analysis of mutations in isocitrate dehydrogenase involved in gliomagenesis
по: Krell, D
Опубликовано: (2014)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
по: Hvinden, IC, и др.
Опубликовано: (2021)

Isocitrate dehydrogenase gene variants in cancer and their clinical significance
по: Cadoux-Hudson, T, и др.
Опубликовано: (2021)

Cytosolic NADP-isocitrate dehydrogenase in Arabidopsis leaves and roots
по: M. Leterrier, и др.
Опубликовано: (2012-12-01)

Isocitrate Dehydrogenase Inhibitors in Glioma: From Bench to Bedside
по: Merve Hazal Ser, и др.
Опубликовано: (2024-05-01)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
по: Danielle Golub, и др.
Опубликовано: (2019-05-01)

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
по: Hamoud Al-Khallaf
Опубликовано: (2017-08-01)

Research Progress of Isocitrate Dehydrogenase Gene Mutation Therapy
по: LIN Meijia, и др.
Опубликовано: (2023-03-01)

Isocitrate dehydrogenase 1 and 2 genes mutations and MGMT methylation in gliomas
по: D. V. Tabakov, и др.
Опубликовано: (2017-04-01)

Advances in Immune Microenvironment and Immunotherapy of Isocitrate Dehydrogenase Mutated Glioma
по: Dongming Yan, и др.
Опубликовано: (2022-06-01)

Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities
по: Liu, S, и др.
Опубликовано: (2020)

Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
по: Pengkai Sun, и др.
Опубликовано: (2020-12-01)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).
по: Jinsung Yang, и др.
Опубликовано: (2017-08-01)

Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications
по: Yang Liu, и др.
Опубликовано: (2020-08-01)

Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
по: Ahmed F. Khalil, и др.
Опубликовано: (2023-12-01)

Isocitrate dehydrogenase 1 mutation subtypes at site 132 and their translational potential in glioma
по: Victor M Lu, и др.
Опубликовано: (2018-01-01)

Isocitrate dehydrogenase 1 mutation is associated with reduced levels of inflammation in glioma patients
по: Auezova R, и др.
Опубликовано: (2019-04-01)

A novel isocitrate dehydrogenase 1 G131D mutation in glioblastoma
по: Lei-Ming Wang, и др.
Опубликовано: (2021-02-01)

The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
по: Katarína Smolková, и др.
Опубликовано: (2012-01-01)

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation
по: Adnan Khan Niazi, и др.
Опубликовано: (2019-01-01)

Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma
по: ZHAO Jingjing, ZHANG Zhihong, ZHEN Junping
Опубликовано: (2024-04-01)

Identification of potential target genes for isocitrate dehydrogenase mutations in cholangiocarcinoma
по: WANG Di, LI Qing, TONG Wei-min, NIU Ya-mei
Опубликовано: (2020-04-01)

Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
по: Ming-Yang Li, и др.
Опубликовано: (2015-01-01)

Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2
по: Raluca-Ioana Stefan-van Staden, и др.
Опубликовано: (2022-01-01)

Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
по: Su Li, и др.
Опубликовано: (2022-05-01)

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods
по: Walsby-Tickle, J
Опубликовано: (2020)