Protein kinase A type I and type II define distinct intracellular signaling compartments.

Protein kinase A type I and type II define distinct intracellular signaling compartments.

Protein kinase A (PKA) is a key regulatory enzyme that, on activation by cAMP, modulates a wide variety of cellular functions. PKA isoforms type I and type II possess different structural features and biochemical characteristics, resulting in nonredundant function. However, how different PKA isoform...

Podrobná bibliografie
Hlavní autoři:	Di Benedetto, G, Zoccarato, A, Lissandron, V, Terrin, A, Li, X, Houslay, MD, Baillie, G, Zaccolo, M
Médium:	Journal article
Jazyk:	English
Vydáno:	2008

Podobné jednotky

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
Autor: Wilson, L, a další
Vydáno: (2011)

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Autor: Mongillo, M, a další
Vydáno: (2004)

Restricted diffusion of a freely diffusible second messenger: Mechanisms underlying compartmentalized cAMP signalling
Autor: Zaccolo, M, a další
Vydáno: (2006)

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling.
Autor: Zaccolo, M, a další
Vydáno: (2006)

Imaging the cAMP-dependent signal transduction pathway
Autor: Zaccolo, M, a další
Vydáno: (2005)

Imaging the cAMP-dependent signal transduction pathway.
Autor: Zaccolo, M, a další
Vydáno: (2005)

Redox-dependent signalling via protein Kinase A type I within distinct subcellular compartments
Autor: Lomas, O
Vydáno: (2016)

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
Autor: Terrin, A, a další
Vydáno: (2006)

Measuring dynamic changes in cAMP using fluorescence resonance energy transfer.
Autor: Evellin, S, a další
Vydáno: (2004)

Study of cyclic adenosine monophosphate microdomains in cells.
Autor: Mongillo, M, a další
Vydáno: (2005)

cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes.
Autor: Stangherlin, A, a další
Vydáno: (2011)

Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments
Autor: William S. Garver, a další
Vydáno: (2000-05-01)

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Autor: Mongillo, M, a další
Vydáno: (2006)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Autor: Bullock, A, a další
Vydáno: (2009)

Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation
Autor: Bullock, A, a další
Vydáno: (2009)

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.
Autor: Oliveira, R, a další
Vydáno: (2010)

RNA splicing programs define tissue compartments and cell types at single-cell resolution
Autor: Julia Eve Olivieri, a další
Vydáno: (2021-09-01)

Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction.
Autor: Lissandron, V, a další
Vydáno: (2005)

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
Autor: Terrin, A, a další
Vydáno: (2012)

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.
Autor: Lissandron, V, a další
Vydáno: (2006)

The Distribution and Role of the CFTR Protein in the Intracellular Compartments
Autor: Agnieszka Lukasiak, a další
Vydáno: (2021-10-01)

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors
Autor: Gesellchen, F, a další
Vydáno: (2011)

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors.
Autor: Gesellchen, F, a další
Vydáno: (2011)

Small-molecule FRET probes for protein kinase activity monitoring in living cells.
Autor: Vaasa, A, a další
Vydáno: (2010)

GPCRs in Intracellular Compartments: New Targets for Drug Discovery
Autor: Irene Fasciani, a další
Vydáno: (2022-09-01)

Shapes of discoid intracellular compartments with small relative volumes.
Autor: Jure Derganc, a další
Vydáno: (2011-01-01)

PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo.
Autor: Röder, I, a další
Vydáno: (2009)

cAMP signaling in subcellular compartments.
Autor: Lefkimmiatis, K, a další
Vydáno: (2014)

Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways
Autor: Harish N Vasudevan, a další
Vydáno: (2015-05-01)

Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments.
Autor: Corina M Stewart, a další
Vydáno: (2021-01-01)

Analysis of compartmentalized cAMP: A method to compare signals from differently targeted FRET reporters
Autor: Stangherlin, A, a další
Vydáno: (2014)

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.
Autor: Stangherlin, A, a další
Vydáno: (2014)

NUTRITION IN TYPE II DIABETES MELLITUS THE ELEPHANT IN THE ROOM
Autor: Peter Baillie
Vydáno: (2024-10-01)

NUTRITION IN TYPE II DIABETES MELLITUS THE ELEPHANT IN THE ROOM
Autor: Peter Baillie
Vydáno: (2024-10-01)

PU.1 Expression Defines Distinct Functional Activities in the Phenotypic HSC Compartment of a Murine Inflammatory Stress Model
Autor: James S. Chavez, a další
Vydáno: (2022-02-01)

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.
Autor: Sin, Y, a další
Vydáno: (2011)

Creatine Kinase Activity in Patients with Diabetes Mellitus Type I and Type II
Autor: Adlija Jevrić-Čaušević, a další
Vydáno: (2006-08-01)

Cellular census of human fibrosis defines functionally distinct stromal cell types and states
Autor: Layton, TB, a další
Vydáno: (2020)

Cellular census of human fibrosis defines functionally distinct stromal cell types and states
Autor: Thomas B. Layton, a další
Vydáno: (2020-06-01)

Self-assembled hydrogel fibers for sensing the multi-compartment intracellular milieu
Autor: Vemula, Praveen Kumar, a další
Vydáno: (2014)