A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1
Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanism of action of a selective non-covalent colorimetric biosensor for the recognition of hNAT1 and its murine homologue, mNat2, over the...
المؤلفون الرئيسيون: | Laurieri, N, Egleton, J, Varney, A, Thinnes, C, Quevedo, C, Seden, P, Thompson, S, Rodrigues-Lima, F, Dairou, J, Dupret, J, Russell, A, Sim, E |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
Public Library of Science
2013
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مواد مشابهة
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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.
حسب: Nicola Laurieri, وآخرون
منشور في: (2014-01-01) -
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
حسب: Laurieri, N, وآخرون
منشور في: (2014) -
Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1) and Mouse nat2 (mnat2)
حسب: Laurieri, N, وآخرون
منشور في: (2010) -
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
حسب: Russell, A, وآخرون
منشور في: (2009) -
Structure and mechanism of arylamine N-acetyltransferases.
حسب: Westwood, I, وآخرون
منشور في: (2006)