A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1

A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1

Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanism of action of a selective non-covalent colorimetric biosensor for the recognition of hNAT1 and its murine homologue, mNat2, over the...

Detaylı Bibliyografya
Asıl Yazarlar:	Laurieri, N, Egleton, J, Varney, A, Thinnes, C, Quevedo, C, Seden, P, Thompson, S, Rodrigues-Lima, F, Dairou, J, Dupret, J, Russell, A, Sim, E
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Public Library of Science 2013

Benzer Materyaller

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2.
Yazar:: Nicola Laurieri, ve diğerleri
Baskı/Yayın Bilgisi: (2014-01-01)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
Yazar:: Laurieri, N, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Optimisation of Isoenzyme-Specific Reagents: Organic Synthesis and Biological Characterisation of Naphthoquinones as Selective Inhibitors of Human n-Acetyltransferase 1 (hnat1) and Mouse nat2 (mnat2)
Yazar:: Laurieri, N, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Yazar:: Russell, A, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Structure and mechanism of arylamine N-acetyltransferases.
Yazar:: Westwood, I, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
Yazar:: Laurieri, N, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
Yazar:: Abuhammad, A, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Arylamine N-acetyltransferase in adult mouse brain
Yazar:: Mo, M, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
Yazar:: Brooke, E
Baskı/Yayın Bilgisi: (2003)

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
Yazar:: Sim, E, ve diğerleri
Baskı/Yayın Bilgisi: (2008)

Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
Yazar:: Wakefield, L, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.
Yazar:: Kawamura, A, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Mapping the genes for arylamine N-acetyltransferases
Yazar:: Fakis, G
Baskı/Yayın Bilgisi: (2000)

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
Yazar:: Brooke, E, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Arylamine N-acetyltransferase expression during murine heart development
Yazar:: Wakefield, L, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Expression of the genes for arylamine N-acetyltransferases in mice
Yazar:: Boukouvala, S, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
Yazar:: Westwood, I, ve diğerleri
Baskı/Yayın Bilgisi: (2011)

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
Yazar:: Kawamura, A, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
Yazar:: Wang, H, ve diğerleri
Baskı/Yayın Bilgisi: (2005)

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
Yazar:: Fullam, E, ve diğerleri
Baskı/Yayın Bilgisi: (2009)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
Yazar:: Abuhammad, A, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
Yazar:: Kawamura, A, ve diğerleri
Baskı/Yayın Bilgisi: (2004)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
Yazar:: Abuhammad, A, ve diğerleri
Baskı/Yayın Bilgisi: (2012)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
Yazar:: Madikane, V, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
Yazar:: Madikane, V, ve diğerleri
Baskı/Yayın Bilgisi: (2007)

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
Yazar:: Westwood, I, ve diğerleri
Baskı/Yayın Bilgisi: (2010)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
Yazar:: Areej Abuhammad, ve diğerleri
Baskı/Yayın Bilgisi: (2012-01-01)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Yazar:: Hiba Chelouti, ve diğerleri
Baskı/Yayın Bilgisi: (2017-08-01)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
Yazar:: Xinning Liu, ve diğerleri
Baskı/Yayın Bilgisi: (2021-01-01)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
Yazar:: Anderton, M, ve diğerleri
Baskı/Yayın Bilgisi: (2006)

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Yazar:: Fullam, E, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Yazar:: Fullam, E, ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
Yazar:: Amjad Mahasneh, ve diğerleri
Baskı/Yayın Bilgisi: (2012-01-01)

Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status
Yazar:: Raúl A. Salazar-González, ve diğerleri
Baskı/Yayın Bilgisi: (2022-01-01)

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.
Yazar:: Sandy, J, ve diğerleri
Baskı/Yayın Bilgisi: (2002)

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
Yazar:: Brooke, E, ve diğerleri
Baskı/Yayın Bilgisi: (2003)

Investigating the endogenous role of human n-acetyltransferase 1, as potential breast cancer biomarker, using chemical biology
Yazar:: Laurieri, N
Baskı/Yayın Bilgisi: (2012)

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Yazar:: Musbah O. M. Tanira, ve diğerleri
Baskı/Yayın Bilgisi: (2003-04-01)

Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes
Yazar:: Christelle Vangenot, ve diğerleri
Baskı/Yayın Bilgisi: (2019-07-01)

Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.
Yazar:: Adam, P, ve diğerleri
Baskı/Yayın Bilgisi: (2003)