The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia

<p><strong>Introduction:</strong> Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest optimal pathwa...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Njunge, JM, Tickell, K, Diallo, AH, Sayeem Bin Shahid, ASM, Gazi, MA, Saleem, A, Kazi, Z, Ali, S, Tigoi, C, Mupere, E, Lancioni, CL, Yoshioka, E, Chisti, MJ, Mburu, M, Ngari, M, Ngao, N, Gichuki, B, Omer, E, Gumbi, W, Singa, B, Bandsma, R, Ahmed, T, Voskuijl, W, Williams, TN, Macharia, A, Makale, J, Mitchel, A, Williams, J, Gogain, J, Janjic, N, Mandal, R, Wishart, DS, Wu, H, Xia, L, Routledge, M, Gong, YY, Espinosa, C, Aghaeepour, N, Liu, J, Houpt, E, Lawley, TD, Browne, H, Shao, Y, Rwigi, D, Kariuki, K, Kaburu, T, Uhlig, HH, Gartner, L, Jones, K, Koulman, A, Walson, J, Berkley, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	F1000Research 2022

Eitemau Tebyg

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]
gan: Albert Koulman, et al.
Cyhoeddwyd: (2022-11-01)

Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV
gan: Mudibo, EO, et al.
Cyhoeddwyd: (2024)

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
gan: Gonzales, GB, et al.
Cyhoeddwyd: (2020)

Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
gan: Gerard Bryan Gonzales, et al.
Cyhoeddwyd: (2020-07-01)

Undernutrition, host immunity and vulnerability to infection among young children
gan: Gwela, A, et al.
Cyhoeddwyd: (2019)

The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition
gan: Gonzales, GB, et al.
Cyhoeddwyd: (2022)

Systemic biological mechanisms underpin poor post-discharge growth among severely wasted children with HIV
gan: Evans O. Mudibo, et al.
Cyhoeddwyd: (2024-11-01)

Systemic inflammation and metabolic disturbances underlie inpatient mortality among ill children with severe malnutrition
gan: Wen, B, et al.
Cyhoeddwyd: (2022)

Biomarkers of post-discharge mortality among children with complicated severe acute malnutrition
gan: Njunge, J, et al.
Cyhoeddwyd: (2019)

The role of albumin and the extracellular matrix on the pathophysiology of oedema formation in severe malnutrition
gan: Gerard Bryan Gonzales, et al.
Cyhoeddwyd: (2022-05-01)

Characterising paediatric mortality during and after acute illness in Sub-Saharan Africa and South Asia: a secondary analysis of the CHAIN cohort using a machine learning approach
gan: Diallo, AH, et al.
Cyhoeddwyd: (2023)

Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study
gan: Njunge, J, et al.
Cyhoeddwyd: (2020)

Neurodevelopment and recovery from wasting
gan: Babikako, HM, et al.
Cyhoeddwyd: (2022)

Evaluating blood culture collection practice in children hospitalized with acute illness at a tertiary hospital in Malawi
gan: Mukhula, VT, et al.
Cyhoeddwyd: (2023)

The role of food insecurity and dietary diversity on recovery from wasting among hospitalized children aged 6–23 months in sub-Saharan Africa and South Asia
gan: Tsegaye, AT, et al.
Cyhoeddwyd: (2022)

Impact of HIV exposure without infection on hospital course and mortality among young children in sub-Saharan Africa: a multi-site cohort study
gan: Lwanga, C, et al.
Cyhoeddwyd: (2024)

Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
gan: Kimenyi, KM, et al.
Cyhoeddwyd: (2024)

Detection of pathogens associated with early-onset neonatal sepsis in cord blood at birth using quantitative PCR
gan: Obiero, CW, et al.
Cyhoeddwyd: (2022)

Intestinal disturbances associated with mortality of children with complicated severe malnutrition
gan: Wen, B, et al.
Cyhoeddwyd: (2023)

Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review.
gan: Kvissberg, M, et al.
Cyhoeddwyd: (2015)

The population dynamics of haemoglobins A, A2, F and S in the context of the haemoglobinopathies HbS and α+thalassaemia in Kenyan infants
gan: Macharia, A, et al.
Cyhoeddwyd: (2018)

Toll-like receptor-induced immune responses during early childhood and their associations with clinical outcomes following acute illness among infants in sub-Saharan Africa
gan: Uebelhoer, LS, et al.
Cyhoeddwyd: (2022)

Minimally invasive postmortem intestinal tissue sampling in malnourished and acutely ill children is feasible and informative
gan: Feutz, E, et al.
Cyhoeddwyd: (2021)

Lactoferrin and lysozyme to promote nutritional, clinical and enteric recovery: a protocol for a factorial, blinded, placebo-controlled randomised trial among children with diarrhoea and malnutrition (the Boresha Afya trial)
gan: Jie Liu, et al.
Cyhoeddwyd: (2024-08-01)

Blood pressure and arterial stiffness in Kenyan adolescents with the sickle cell trait
gan: Etyang, A, et al.
Cyhoeddwyd: (2017)

A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism
gan: Mehakpreet K. Thind, et al.
Cyhoeddwyd: (2024-01-01)

Phenotypic and molecular characterization of β-lactamase-producing Klebsiella species among children discharged from hospital in Western Kenya
gan: Doreen Rwigi, et al.
Cyhoeddwyd: (2024-04-01)

Prevalence and Factors Associated with Hypocholesterolemia among Adults with Bacteriologically Confirmed Pulmonary TB in Kampala
gan: J. Mukisa, et al.
Cyhoeddwyd: (2017-04-01)

Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study [version 2; peer review: 2 approved]
gan: James M. Njunge, et al.
Cyhoeddwyd: (2021-03-01)

Caregivers’ Nutrition Knowledge and Dietary Intake of Type 1 Diabetic Children Aged 3–14 Years in Uganda
gan: Ndahura NB, et al.
Cyhoeddwyd: (2021-01-01)

Design and application of a novel two-amplicon approach for defining eukaryotic microbiota
gan: Ana Popovic, et al.
Cyhoeddwyd: (2018-12-01)

Clinical epidemiology of COVID-19 among hospitalized children in rural western Kenya
gan: Tsegaye, AT, et al.
Cyhoeddwyd: (2023)

The impact of malaria-protective red blood cell polymorphisms on parasite biomass in children with severe Plasmodium falciparum malaria
gan: S. Uyoga, et al.
Cyhoeddwyd: (2022-06-01)

Impact of HIV exposure without infection on hospital course and mortality among young children in sub-Saharan Africa: a multi-site cohort study
gan: Christopher Lwanga, et al.
Cyhoeddwyd: (2024-12-01)

Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya
gan: Shah, S, et al.
Cyhoeddwyd: (2014)

Do the same genes predispose to Gilles de la Tourette syndrome and dystonia? Report of a new family and review of the literature.
gan: Németh, A, et al.
Cyhoeddwyd: (1999)

Blood pressure and arterial stiffness in Kenyan adolescents with α+thalassemia
gan: Etyang, A, et al.
Cyhoeddwyd: (2017)

Childhood growth during recovery from acute illness in Africa and South Asia: a secondary analysis of the childhood acute illness and nutrition (CHAIN) prospective cohortResearch in context
gan: Celine Bourdon, et al.
Cyhoeddwyd: (2024-04-01)

Prevalence and correlates of paediatric guideline non-adherence for initial empirical care in six low and middle-income settings: a hospital-based cross-sectional study
gan: Tahmeed Ahmed, et al.
Cyhoeddwyd: (2024-03-01)

Improving water and hand-washing services in rural health care facilities in Kitui County, Kenya
gan: Katuva, J, et al.
Cyhoeddwyd: (2022)