In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor. Using northern blotting and RT-PCR, LKB1 has been reported to be expressed widely in human adult tissues, although in Xenopus the expression of its homologue, XEEK1, is apparently restr...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Rowan, A, Churchman, M, Jefferey, R, Hanby, A, Poulsom, R, Tomlinson, I
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2000

समान संसाधन

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Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.
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Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.
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प्रकाशित: (2023-04-01)

Sequence changes in predicted promoter elements of STK11/LKB1 are unlikely to contribute to Peutz-Jeghers syndrome.
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प्रकाशित: (2005)

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Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.
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Sequence changes in predicted promoter elements of <it>STK11/LKB1 </it>are unlikely to contribute to Peutz-Jeghers syndrome
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Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice.
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The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours.
द्वारा: Sawyer, E, और अन्य
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Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
द्वारा: Wang, Z, और अन्य
प्रकाशित: (1999)

Mutations in normal breast tissue and breast tumours.
द्वारा: Tomlinson, I
प्रकाशित: (2001)

Beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast.
द्वारा: Sawyer, E, और अन्य
प्रकाशित: (2003)

Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit.
द्वारा: Sawyer, E, और अन्य
प्रकाशित: (2003)

Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
द्वारा: Wang, Z, और अन्य
प्रकाशित: (1998)

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.
द्वारा: Rowan, A, और अन्य
प्रकाशित: (1999)

Mutations in <it>STK11 </it>gene in Czech Peutz-Jeghers patients
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Normal and Tumour Tissue mRNA Expressions of Telomerase Complex Genes in Several Types of Cancer
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STK11 genetic alterations in metastatic EGFR mutant lung cancer
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प्रकाशित: (2025-02-01)

Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
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प्रकाशित: (2017-06-01)

Elucidating the role of Lkb1 and mTOR in adipose tissue
द्वारा: Ziye Xu, और अन्य
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LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors
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Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants through Conformational Sampling Approach
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प्रकाशित: (2016-01-01)

Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach
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प्रकाशित: (2016-04-01)

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.
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प्रकाशित: (2014-01-01)

A novel mutation in <it>STK11 </it>gene is associated with Peutz-Jeghers Syndrome in Indian patients
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Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines.
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The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
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High prevalence of germline <it>STK11 </it>mutations in Hungarian Peutz-Jeghers Syndrome patients
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प्रकाशित: (2010-11-01)