Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

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To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously functionally uncharacterized product of the human DHRS10 gene is endowed with 17beta-HSD (17beta-hydroxysteroid dehydrogenase) activity. 17b...

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Detalhes bibliográficos
Main Authors: Lukacik, P, Keller, B, Bunkoczi, G, Kavanagh, K, Lee, W, Adamski, J, Oppermann, U
Formato: Journal article
Idioma:English
Publicado em: 2007
Assuntos:
chemistry
Models, Molecular
Amino Acid Sequence
Structural Homology, Protein
Cytosol
Protein Structure, Tertiary
enzymology
NAD
Ligands
Cell Line
Sequence Alignment
genetics
Kinetics
Molecular Sequence Data
Gene Expression
Protein Structure, Secondary
Binding Sites
17-Hydroxysteroid Dehydrogenases
Crystallography, X-Ray
Organ Specificity
isolation and purification
Oxidation-Reduction
metabolism
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