Evolution of a cycloaddition-rearrangement approach to the squalestatins: a quarter-century odyssey
The highs, lows, and diversions of a journey leading to two syntheses of 6,7-dideoxysqualestatin H5 is described. Both syntheses relied on highly diastereoselective n -alkylations of a tartrate acetonide enolate and subsequent oxidation-hydrolysis to provide an asymmetric entry to β-hydrox...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
Thieme Publishing
2020
|